Butyrylcholinesterase K variant is genetically associated with late onset Alzheimer's disease in Northern Ireland

S P McIlroy, V L Crawford, K B Dynan, B M McGleenon, M D Vahidassr, J T Lawson, A P Passmore

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48 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that has been associated, sometimes controversially, with polymorphisms in a number of genes. Recently the butyrylcholinesterase K variant (BCHE K) allele has been shown to act in synergy with the apolipoprotein E epsilon4 (APOE epsilon4) allele to promote risk for AD. Most subsequent replicative studies have been unable to confirm these findings. We have conducted a case-control association study using a clinically well defined group of late onset AD patients (n=175) and age and sex matched control subjects (n=187) from the relatively genetically homogeneous Northern Ireland population to test this association. The BCHE genotypes of patients were found to be significantly different from controls (chi(2)=23.68, df=2, p
Original languageEnglish
Pages (from-to)182-185
Number of pages4
JournalJournal of Medical Genetics
Volume37
Issue number3
Publication statusPublished - 2000

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