C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease: the BiomarCaRE project

Natalie Arnold, Christopher Blaum, Alina Goßling, Fabian J Brunner, Benjamin Bay, Marco M Ferrario, Paolo Brambilla, Giancarlo Cesana, Valerio Leoni, Luigi Palmieri, Chiara Donfrancesco, Teresa Padró, Jonas Andersson, Pekka Jousilahti, Francisco Ojeda, Tanja Zeller, Allan Linneberg, Stefan Söderberg, Licia Iacoviello, Francesco GianfagnaSusana Sans, Giovanni Veronesi, Barbara Thorand, Annette Peters, Hugh Tunstall-Pedoe, Frank Kee, Veikko Salomaa, Renate B Schnabel, Kari Kuulasmaa, Stefan Blankenberg, Wolfgang Koenig, Christoph Waldeyer

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Recent investigations have suggested an interdependence of lipoprotein(a) [Lp(a)]-related risk for cardiovascular disease with background inflammatory burden. The aim the present analysis was to investigate whether high-sensitive C-reactive protein (hsCRP) modulates the association between Lp(a) and coronary heart disease (CHD) in the general population. Data from 71 678 participants from 8 European prospective population-based cohort studies were used (65 661 without/6017 with established CHD at baseline; median follow-up 9.8/13.8 years, respectively). Fine and Gray competing risk-adjusted models were calculated according to accompanying hsCRP concentration (
Original languageEnglish
Pages (from-to)1043–1054
JournalEuropean Heart Journal
Volume45
Issue number12
Early online date18 Jan 2024
DOIs
Publication statusPublished - 21 Mar 2024

Keywords

  • Coronary heart disease
  • Epidemiology
  • Lipoprotein(a)
  • General population
  • High-sensitive C-reactive protein

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