C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease: the BiomarCaRE project

Natalie Arnold; Christopher Blaum; Alina Goßling; Fabian J Brunner; Benjamin Bay; Marco M Ferrario; Paolo Brambilla; Giancarlo Cesana; Valerio Leoni; Luigi Palmieri; Chiara Donfrancesco; Teresa Padró; Jonas Andersson; Pekka Jousilahti; Francisco Ojeda; Tanja Zeller; Allan Linneberg; Stefan Söderberg; Licia Iacoviello; Francesco Gianfagna; Susana Sans; Giovanni Veronesi; Barbara Thorand; Annette Peters; Hugh Tunstall-Pedoe; Frank Kee; Veikko Salomaa; Renate B Schnabel; Kari Kuulasmaa; Stefan Blankenberg; Wolfgang Koenig; Christoph Waldeyer

doi:10.1093/eurheartj/ehad867

C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease: the BiomarCaRE project

Natalie Arnold
, Christopher Blaum
, Alina Goßling
, Fabian J Brunner
, Benjamin Bay
, Marco M Ferrario
, Paolo Brambilla
, Giancarlo Cesana
, Valerio Leoni
, Luigi Palmieri
, Chiara Donfrancesco
, Teresa Padró
, Jonas Andersson
, Pekka Jousilahti
, Francisco Ojeda
, Tanja Zeller
, Allan Linneberg
, Stefan Söderberg
, Licia Iacoviello
, Francesco Gianfagna

Susana Sans, Giovanni Veronesi, Barbara Thorand, Annette Peters, Hugh Tunstall-Pedoe, Frank Kee, Veikko Salomaa, Renate B Schnabel, Kari Kuulasmaa, Stefan Blankenberg, Wolfgang Koenig, Christoph Waldeyer

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Recent investigations have suggested an interdependence of lipoprotein(a) [Lp(a)]-related risk for cardiovascular disease with background inflammatory burden. The aim the present analysis was to investigate whether high-sensitive C-reactive protein (hsCRP) modulates the association between Lp(a) and coronary heart disease (CHD) in the general population. Data from 71 678 participants from 8 European prospective population-based cohort studies were used (65 661 without/6017 with established CHD at baseline; median follow-up 9.8/13.8 years, respectively). Fine and Gray competing risk-adjusted models were calculated according to accompanying hsCRP concentration (

Original language	English
Pages (from-to)	1043–1054
Journal	European Heart Journal
Volume	45
Issue number	12
Early online date	18 Jan 2024
DOIs	https://doi.org/10.1093/eurheartj/ehad867
Publication status	Published - 21 Mar 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Coronary heart disease
Epidemiology
Lipoprotein(a)
General population
High-sensitive C-reactive protein

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10.1093/eurheartj/ehad867Licence: Unspecified

Cite this

Arnold, N., Blaum, C., Goßling, A., Brunner, F. J., Bay, B., Ferrario, M. M., Brambilla, P., Cesana, G., Leoni, V., Palmieri, L., Donfrancesco, C., Padró, T., Andersson, J., Jousilahti, P., Ojeda, F., Zeller, T., Linneberg, A., Söderberg, S., Iacoviello, L., ... Waldeyer, C. (2024). C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease: the BiomarCaRE project. European Heart Journal, 45(12), 1043–1054. https://doi.org/10.1093/eurheartj/ehad867

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title = "C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease: the BiomarCaRE project",

abstract = "Recent investigations have suggested an interdependence of lipoprotein(a) [Lp(a)]-related risk for cardiovascular disease with background inflammatory burden. The aim the present analysis was to investigate whether high-sensitive C-reactive protein (hsCRP) modulates the association between Lp(a) and coronary heart disease (CHD) in the general population. Data from 71 678 participants from 8 European prospective population-based cohort studies were used (65 661 without/6017 with established CHD at baseline; median follow-up 9.8/13.8 years, respectively). Fine and Gray competing risk-adjusted models were calculated according to accompanying hsCRP concentration (",

keywords = "Coronary heart disease, Epidemiology, Lipoprotein(a), General population, High-sensitive C-reactive protein",

author = "Natalie Arnold and Christopher Blaum and Alina Go{\ss}ling and Brunner, \{Fabian J\} and Benjamin Bay and Ferrario, \{Marco M\} and Paolo Brambilla and Giancarlo Cesana and Valerio Leoni and Luigi Palmieri and Chiara Donfrancesco and Teresa Padr{\'o} and Jonas Andersson and Pekka Jousilahti and Francisco Ojeda and Tanja Zeller and Allan Linneberg and Stefan S{\"o}derberg and Licia Iacoviello and Francesco Gianfagna and Susana Sans and Giovanni Veronesi and Barbara Thorand and Annette Peters and Hugh Tunstall-Pedoe and Frank Kee and Veikko Salomaa and Schnabel, \{Renate B\} and Kari Kuulasmaa and Stefan Blankenberg and Wolfgang Koenig and Christoph Waldeyer",

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doi = "10.1093/eurheartj/ehad867",

language = "English",

volume = "45",

pages = "1043–1054",

journal = "European Heart Journal",

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Arnold, N, Blaum, C, Goßling, A, Brunner, FJ, Bay, B, Ferrario, MM, Brambilla, P, Cesana, G, Leoni, V, Palmieri, L, Donfrancesco, C, Padró, T, Andersson, J, Jousilahti, P, Ojeda, F, Zeller, T, Linneberg, A, Söderberg, S, Iacoviello, L, Gianfagna, F, Sans, S, Veronesi, G, Thorand, B, Peters, A, Tunstall-Pedoe, H, Kee, F, Salomaa, V, Schnabel, RB, Kuulasmaa, K, Blankenberg, S, Koenig, W & Waldeyer, C 2024, 'C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease: the BiomarCaRE project', European Heart Journal, vol. 45, no. 12, pp. 1043–1054. https://doi.org/10.1093/eurheartj/ehad867

TY - JOUR

T1 - C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease: the BiomarCaRE project

AU - Arnold, Natalie

AU - Blaum, Christopher

AU - Goßling, Alina

AU - Brunner, Fabian J

AU - Bay, Benjamin

AU - Ferrario, Marco M

AU - Brambilla, Paolo

AU - Cesana, Giancarlo

AU - Leoni, Valerio

AU - Palmieri, Luigi

AU - Donfrancesco, Chiara

AU - Padró, Teresa

AU - Andersson, Jonas

AU - Jousilahti, Pekka

AU - Ojeda, Francisco

AU - Zeller, Tanja

AU - Linneberg, Allan

AU - Söderberg, Stefan

AU - Iacoviello, Licia

AU - Gianfagna, Francesco

AU - Sans, Susana

AU - Veronesi, Giovanni

AU - Thorand, Barbara

AU - Peters, Annette

AU - Tunstall-Pedoe, Hugh

AU - Kee, Frank

AU - Salomaa, Veikko

AU - Schnabel, Renate B

AU - Kuulasmaa, Kari

AU - Blankenberg, Stefan

AU - Koenig, Wolfgang

AU - Waldeyer, Christoph

PY - 2024/3/21

Y1 - 2024/3/21

N2 - Recent investigations have suggested an interdependence of lipoprotein(a) [Lp(a)]-related risk for cardiovascular disease with background inflammatory burden. The aim the present analysis was to investigate whether high-sensitive C-reactive protein (hsCRP) modulates the association between Lp(a) and coronary heart disease (CHD) in the general population. Data from 71 678 participants from 8 European prospective population-based cohort studies were used (65 661 without/6017 with established CHD at baseline; median follow-up 9.8/13.8 years, respectively). Fine and Gray competing risk-adjusted models were calculated according to accompanying hsCRP concentration (

AB - Recent investigations have suggested an interdependence of lipoprotein(a) [Lp(a)]-related risk for cardiovascular disease with background inflammatory burden. The aim the present analysis was to investigate whether high-sensitive C-reactive protein (hsCRP) modulates the association between Lp(a) and coronary heart disease (CHD) in the general population. Data from 71 678 participants from 8 European prospective population-based cohort studies were used (65 661 without/6017 with established CHD at baseline; median follow-up 9.8/13.8 years, respectively). Fine and Gray competing risk-adjusted models were calculated according to accompanying hsCRP concentration (

KW - Coronary heart disease

KW - Epidemiology

KW - Lipoprotein(a)

KW - General population

KW - High-sensitive C-reactive protein

U2 - 10.1093/eurheartj/ehad867

DO - 10.1093/eurheartj/ehad867

M3 - Article

C2 - 38240386

SN - 0195-668X

VL - 45

SP - 1043

EP - 1054

JO - European Heart Journal

JF - European Heart Journal

IS - 12

ER -

C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease: the BiomarCaRE project

Abstract

UN SDGs

Keywords

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