Caging NLRP3 tames inflammasome activity

Kate Schroder, Rebecca C Coll

Research output: Contribution to journalArticle

Abstract

How the danger sensor NLRP3 is activated is intensively debated. Using cryo-electron microscopy (EM) approaches, Andreeva and colleagues made the remarkable discovery that inactive NLRP3 forms a double ring of 12-16 monomers that shield its pyrin domains from the cytosol. We discuss this surprising new mechanism of inflammasome regulation.
Original languageEnglish
Pages (from-to)6224-6226
Number of pages3
JournalCell
Volume184
Issue number26
DOIs
Publication statusPublished - 22 Dec 2021

Bibliographical note

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords

  • Cryoelectron Microscopy
  • Cytosol
  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein

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