How the danger sensor NLRP3 is activated is intensively debated. Using cryo-electron microscopy (EM) approaches, Andreeva and colleagues made the remarkable discovery that inactive NLRP3 forms a double ring of 12-16 monomers that shield its pyrin domains from the cytosol. We discuss this surprising new mechanism of inflammasome regulation.
Bibliographical noteCopyright © 2021 Elsevier Inc. All rights reserved.
- Cryoelectron Microscopy
- NLR Family, Pyrin Domain-Containing 3 Protein