Calcipotriol nanosuspension-loaded trilayer dissolving microneedle patches for the treatment of psoriasis: in vitro delivery and in vivo antipsoriatic activity studies

Xianbing Dai, Andi Dian Permana, Mingshan Li, Habibie, Muhammad Nur Amir, Ke Peng, Chunyang Zhang, Haodong Dai, Alejandro J Paredes, Lalitkumar K. Vora*, Ryan F. Donnelly*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Downloads (Pure)

Abstract

Psoriasis, affecting 2–3% of the global population, is a chronic inflammatory skin condition without a definitive cure. Current treatments focus on managing symptoms. Recognizing the need for innovative drug delivery methods to enhance patient adherence, this study explores a new approach using calcipotriol monohydrate (CPM), a primary topical treatment for psoriasis. Despite its effectiveness, CPM’s therapeutic potential is often limited by factors like the greasiness of topical applications, poor skin permeability, low skin retention, and lack of controlled delivery. To overcome these challenges, the study introduces CPM in the form of nanosuspensions (NSs), characterized by an average particle size of 211 ± 2 nm. These CPM NSs are then incorporated into a trilayer dissolving microneedle patch (MAP) made from poly(vinylpyrrolidone) and w poly(vinyl alcohol) as needle arrays and prefrom 3D printed polylactic acid backing layer. This MAP features rapidly dissolving tips and exhibits good mechanical properties and insertion capability with delivery efficiency compared to the conventional Daivonex ointment. The effectiveness of this novel MAP was tested on Sprague–Dawley rats with imiquimod-induced psoriasis, demonstrating efficacy comparable to the marketed ointment. This innovative trilayer dissolving MAP represents a promising new local delivery system for calcipotriol, potentially revolutionizing psoriasis treatment by enhancing drug delivery and patient compliance.

Original languageEnglish
Pages (from-to)2813-2827
Number of pages15
JournalMolecular Pharmaceutics
Volume21
Issue number6
Early online date16 May 2024
DOIs
Publication statusPublished - 03 Jun 2024

Keywords

  • calcipotriol
  • microneedle
  • nanocrystal
  • nanosuspension
  • psoriasis

Fingerprint

Dive into the research topics of 'Calcipotriol nanosuspension-loaded trilayer dissolving microneedle patches for the treatment of psoriasis: in vitro delivery and in vivo antipsoriatic activity studies'. Together they form a unique fingerprint.

Cite this