Calcium and Ca2+/Calmodulin-dependent kinase II as targets for helminth parasite control

Sujeevi S K Nawaratna, Hong You, Malcolm K Jones, Donald P McManus, Geoffrey N Gobert

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

In eukaryotes, effective calcium homeostasis is critical for many key biological processes. There is an added level of complexity in parasites, particularly multicellular helminth worms, which modulate calcium levels while inhabiting the host microenvironment. Parasites ensure efficient calcium homeostasis through gene products, such as the calmodulin-dependent kinases (CaMK), the main focus of this review. The importance of CaMK is becoming increasingly apparent from recent functional studies of helminth and protozoan parasites. Investigations on the molecular regulation of calcium and the role of CaMK are important for both supplementing current drug regimens and finding new antiparasitic compounds. Whereas calcium regulators, including CaMK, are well characterised in mammalian systems, knowledge of their functional properties in parasites is increasing but is still in its infancy.

Original languageEnglish
Pages (from-to)1743-1751
Number of pages9
JournalBiochemical society transactions
Volume46
Issue number6
Early online date12 Nov 2018
DOIs
Publication statusEarly online date - 12 Nov 2018

Bibliographical note

© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

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