Can More High-Risk Cardiovascular Patients be Identified Using Novel Biomarkers? Extending the msm Package to Measure Reclassification.

Felicity Lamrock, Karen Cairns, Annette Conrads-Frank, Frank Kee, Veikko Salomaa, Uwe Siebert

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Numerous novel biomarkers are being considered as tools to enhance cardiovascular risk estimation. Statistical models can indicate how a biomarker influences movements between health states, and clinicians are interested in the impact they may have compared to traditional risk factors alone. Net reclassification indices (NRIs) have recently become popular statistics for measuring the prediction increment of new biomarkers. The msm package within R can fit multi-state models to longitudinal data, giving output for all permitted state-to-state transitions within the one calculation. However its usefulness could be further enhanced through its extension to include NRIs. This paper focuses on extending the msm package to enable NRIs to be calculated. The results are demonstrated for cardiovascular data, with the inclusion of a panel of novel biomarkers (CRP, NT-pro BNP, and troponin I) giving rise to a NRI of 0.2089 for males and 0.1678 for females.
Original languageEnglish
Title of host publicationIEEE 29th International Symposium on Computer-Based Medical Systems (CBMS) 20-24 June 2016
Publisher IEEE
Pages203-204
Publication statusPublished - 18 Aug 2016

Publication series

Name 29th International Symposium on Computer-Based Medical Systems
PublisherIEEE
ISSN (Electronic)2372-9198

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Biomarkers
Health
Statistics

Cite this

Lamrock, F., Cairns, K., Conrads-Frank, A., Kee, F., Salomaa, V., & Siebert, U. (2016). Can More High-Risk Cardiovascular Patients be Identified Using Novel Biomarkers? Extending the msm Package to Measure Reclassification. In IEEE 29th International Symposium on Computer-Based Medical Systems (CBMS) 20-24 June 2016 (pp. 203-204). ( 29th International Symposium on Computer-Based Medical Systems). IEEE .
Lamrock, Felicity ; Cairns, Karen ; Conrads-Frank, Annette ; Kee, Frank ; Salomaa, Veikko ; Siebert, Uwe. / Can More High-Risk Cardiovascular Patients be Identified Using Novel Biomarkers? Extending the msm Package to Measure Reclassification. IEEE 29th International Symposium on Computer-Based Medical Systems (CBMS) 20-24 June 2016. IEEE , 2016. pp. 203-204 ( 29th International Symposium on Computer-Based Medical Systems).
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title = "Can More High-Risk Cardiovascular Patients be Identified Using Novel Biomarkers? Extending the msm Package to Measure Reclassification.",
abstract = "Numerous novel biomarkers are being considered as tools to enhance cardiovascular risk estimation. Statistical models can indicate how a biomarker influences movements between health states, and clinicians are interested in the impact they may have compared to traditional risk factors alone. Net reclassification indices (NRIs) have recently become popular statistics for measuring the prediction increment of new biomarkers. The msm package within R can fit multi-state models to longitudinal data, giving output for all permitted state-to-state transitions within the one calculation. However its usefulness could be further enhanced through its extension to include NRIs. This paper focuses on extending the msm package to enable NRIs to be calculated. The results are demonstrated for cardiovascular data, with the inclusion of a panel of novel biomarkers (CRP, NT-pro BNP, and troponin I) giving rise to a NRI of 0.2089 for males and 0.1678 for females.",
author = "Felicity Lamrock and Karen Cairns and Annette Conrads-Frank and Frank Kee and Veikko Salomaa and Uwe Siebert",
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Lamrock, F, Cairns, K, Conrads-Frank, A, Kee, F, Salomaa, V & Siebert, U 2016, Can More High-Risk Cardiovascular Patients be Identified Using Novel Biomarkers? Extending the msm Package to Measure Reclassification. in IEEE 29th International Symposium on Computer-Based Medical Systems (CBMS) 20-24 June 2016. 29th International Symposium on Computer-Based Medical Systems, IEEE , pp. 203-204.

Can More High-Risk Cardiovascular Patients be Identified Using Novel Biomarkers? Extending the msm Package to Measure Reclassification. / Lamrock, Felicity; Cairns, Karen; Conrads-Frank, Annette; Kee, Frank; Salomaa, Veikko; Siebert, Uwe.

IEEE 29th International Symposium on Computer-Based Medical Systems (CBMS) 20-24 June 2016. IEEE , 2016. p. 203-204 ( 29th International Symposium on Computer-Based Medical Systems).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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T1 - Can More High-Risk Cardiovascular Patients be Identified Using Novel Biomarkers? Extending the msm Package to Measure Reclassification.

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AB - Numerous novel biomarkers are being considered as tools to enhance cardiovascular risk estimation. Statistical models can indicate how a biomarker influences movements between health states, and clinicians are interested in the impact they may have compared to traditional risk factors alone. Net reclassification indices (NRIs) have recently become popular statistics for measuring the prediction increment of new biomarkers. The msm package within R can fit multi-state models to longitudinal data, giving output for all permitted state-to-state transitions within the one calculation. However its usefulness could be further enhanced through its extension to include NRIs. This paper focuses on extending the msm package to enable NRIs to be calculated. The results are demonstrated for cardiovascular data, with the inclusion of a panel of novel biomarkers (CRP, NT-pro BNP, and troponin I) giving rise to a NRI of 0.2089 for males and 0.1678 for females.

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Lamrock F, Cairns K, Conrads-Frank A, Kee F, Salomaa V, Siebert U. Can More High-Risk Cardiovascular Patients be Identified Using Novel Biomarkers? Extending the msm Package to Measure Reclassification. In IEEE 29th International Symposium on Computer-Based Medical Systems (CBMS) 20-24 June 2016. IEEE . 2016. p. 203-204. ( 29th International Symposium on Computer-Based Medical Systems).