Can the HB-EGF/EGFR pathway restore injured neurons?

Colin Adrain, Marina Badenes

Research output: Contribution to journalArticlepeer-review


Heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) is a transmembrane protein that, when cleaved by metalloproteases through a process called ectodomain shedding, binds to the EGF receptor (EGFR), activating downstream signaling. The HB‐EGF/EGFR pathway is crucial in development and is involved in numerous pathophysiological processes. In this issue of The FEBS Journal, Sireci et al. reveal a previously unexplored function of the HB‐EGF/EGFR pathway in promoting neuronal progenitor proliferation and sensory neuron regeneration in the zebrafish olfactory epithelium in response to injury.
Original languageEnglish
JournalThe FEBS Journal
Early online date29 Apr 2024
Publication statusEarly online date - 29 Apr 2024


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