Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility

D.T. Leong; J. Lim; X. Goh; J. Pratap; B.P. Pereira; H.S. Kwok; S.S. Nathan; J.R. Dobson; J.B. Lian; Y. Ito; P.M. Voorhoeve; G.S. Stein; Manuel Salto-Tellez; S.M. Cool; A.J. Van Wijnen

doi:10.1186/bcr2762

Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility

D.T. Leong, J. Lim, X. Goh, J. Pratap, B.P. Pereira, H.S. Kwok, S.S. Nathan, J.R. Dobson, J.B. Lian, Y. Ito, P.M. Voorhoeve, G.S. Stein, Manuel Salto-Tellez, S.M. Cool, A.J. Van Wijnen

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Introduction: Metastatic breast cancer cells frequently and ectopically express the transcription factor RUNX2, which normally attenuates proliferation and promotes maturation of osteoblasts. RUNX2 expression is inversely regulated with respect to cell growth in osteoblasts and deregulated in osteosarcoma cells.

Original language	English
Article number	R89
Journal	Breast Cancer Research
Volume	12
Issue number	5
DOIs	https://doi.org/10.1186/bcr2762
Publication status	Published - 28 Oct 2010

ASJC Scopus subject areas

Cancer Research
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/bcr2762

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Leong, D. T., Lim, J., Goh, X., Pratap, J., Pereira, B. P., Kwok, H. S., Nathan, S. S., Dobson, J. R., Lian, J. B., Ito, Y., Voorhoeve, P. M., Stein, G. S., Salto-Tellez, M., Cool, S. M., & Van Wijnen, A. J. (2010). Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility. Breast Cancer Research, 12(5), Article R89. https://doi.org/10.1186/bcr2762

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title = "Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility",

abstract = "Introduction: Metastatic breast cancer cells frequently and ectopically express the transcription factor RUNX2, which normally attenuates proliferation and promotes maturation of osteoblasts. RUNX2 expression is inversely regulated with respect to cell growth in osteoblasts and deregulated in osteosarcoma cells.",

author = "D.T. Leong and J. Lim and X. Goh and J. Pratap and B.P. Pereira and H.S. Kwok and S.S. Nathan and J.R. Dobson and J.B. Lian and Y. Ito and P.M. Voorhoeve and G.S. Stein and Manuel Salto-Tellez and S.M. Cool and {Van Wijnen}, A.J.",

year = "2010",

month = oct,

day = "28",

doi = "10.1186/bcr2762",

language = "English",

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Leong, DT, Lim, J, Goh, X, Pratap, J, Pereira, BP, Kwok, HS, Nathan, SS, Dobson, JR, Lian, JB, Ito, Y, Voorhoeve, PM, Stein, GS, Salto-Tellez, M, Cool, SM & Van Wijnen, AJ 2010, 'Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility', Breast Cancer Research, vol. 12, no. 5, R89. https://doi.org/10.1186/bcr2762

TY - JOUR

T1 - Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility

AU - Leong, D.T.

AU - Lim, J.

AU - Goh, X.

AU - Pratap, J.

AU - Pereira, B.P.

AU - Kwok, H.S.

AU - Nathan, S.S.

AU - Dobson, J.R.

AU - Lian, J.B.

AU - Ito, Y.

AU - Voorhoeve, P.M.

AU - Stein, G.S.

AU - Salto-Tellez, Manuel

AU - Cool, S.M.

AU - Van Wijnen, A.J.

PY - 2010/10/28

Y1 - 2010/10/28

N2 - Introduction: Metastatic breast cancer cells frequently and ectopically express the transcription factor RUNX2, which normally attenuates proliferation and promotes maturation of osteoblasts. RUNX2 expression is inversely regulated with respect to cell growth in osteoblasts and deregulated in osteosarcoma cells.

AB - Introduction: Metastatic breast cancer cells frequently and ectopically express the transcription factor RUNX2, which normally attenuates proliferation and promotes maturation of osteoblasts. RUNX2 expression is inversely regulated with respect to cell growth in osteoblasts and deregulated in osteosarcoma cells.

U2 - 10.1186/bcr2762

DO - 10.1186/bcr2762

M3 - Article

SN - 1465-542X

VL - 12

JO - Breast Cancer Research

JF - Breast Cancer Research

IS - 5

M1 - R89

ER -

Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility

Abstract

ASJC Scopus subject areas

UN SDGs

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