Cancer stem cells and their therapeutic applications [Book]

Eiman Abdel Meguid; Ahmed El-Hashash

doi:10.1007/978-3-319-98065-2_1

Cancer stem cells and their therapeutic applications [Book]

Eiman Abdel Meguid
, Ahmed El-Hashash

School of Medicine, Dentistry and Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract

Cancer is currently a major health problem that impacts human life worldwide. Several studies support the concept of stem cells in cancerogenesis. The cancer stem cell (CSC) population is tumorigenic and displays characteristic markers and properties of stem cells, including self- renewal/proliferation and differentiation. CSCs can play an important role in carcinogenesis. Many therapeutic strategies currently focus on ablating the subpopulation of CSCs using different approaches such as the overcoming of CSC resistance mechanisms or targeting key molecular pathways controlling these cells. Although these therapeutic strategies have few reported side effects, new strategies are still needed. In this chapter, we describe accumulated data on the stem cell concept of cancerogenesis, how dysregulation of stem cell self-renewal affects cancer transformation, and the roles of CSCs in cancer therapy. We also discuss how improving our current understanding of the biology, behavior, and environment of CSCs can help in advancing their applications in cancer therapies, and devising more effective therapeutic strategies and approaches for cancer.

Title of the host publication: Stem cells for cancer and genetic disease treatment. ed.
Series: Stem Cells in Clinical Applications

Original language	English
Title of host publication	Stem cells for cancer and genetic disease treatment
Editors	Phuc Van Pham, Ahmed El-Hashash
Publisher	Springer Nature Switzerland
Chapter	1
Pages	3–12
ISBN (Electronic)	9783319980652
ISBN (Print)	9783319980645
DOIs	https://doi.org/10.1007/978-3-319-98065-2_1
Publication status	Published - 08 Nov 2018

Publication series

Name	Stem Cells in Clinical Applications
ISSN (Print)	2365-4198
ISSN (Electronic)	2365-4201

Bibliographical note

Stem Cells for Cancer Treatment Book Chapter in the "Cancer Stem Cells and Their Therapeutic Applications" Book Authors - Eiman Abdel Meguid and Ahmed El-Hashash. This book is available at QUB library

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1007/978-3-319-98065-2_1Licence: Unspecified

Cite this

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title = "Cancer stem cells and their therapeutic applications [Book]",

abstract = "Cancer is currently a major health problem that impacts human life worldwide. Several studies support the concept of stem cells in cancerogenesis. The cancer stem cell (CSC) population is tumorigenic and displays characteristic markers and properties of stem cells, including self- renewal/proliferation and differentiation. CSCs can play an important role in carcinogenesis. Many therapeutic strategies currently focus on ablating the subpopulation of CSCs using different approaches such as the overcoming of CSC resistance mechanisms or targeting key molecular pathways controlling these cells. Although these therapeutic strategies have few reported side effects, new strategies are still needed. In this chapter, we describe accumulated data on the stem cell concept of cancerogenesis, how dysregulation of stem cell self-renewal affects cancer transformation, and the roles of CSCs in cancer therapy. We also discuss how improving our current understanding of the biology, behavior, and environment of CSCs can help in advancing their applications in cancer therapies, and devising more effective therapeutic strategies and approaches for cancer. Title of the host publication: Stem cells for cancer and genetic disease treatment. ed. Series: Stem Cells in Clinical Applications ",

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Cancer stem cells and their therapeutic applications [Book]. / Abdel Meguid, Eiman; El-Hashash, Ahmed.
Stem cells for cancer and genetic disease treatment. ed. / Phuc Van Pham; Ahmed El-Hashash. Springer Nature Switzerland, 2018. p. 3–12 (Stem Cells in Clinical Applications ).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

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N2 - Cancer is currently a major health problem that impacts human life worldwide. Several studies support the concept of stem cells in cancerogenesis. The cancer stem cell (CSC) population is tumorigenic and displays characteristic markers and properties of stem cells, including self- renewal/proliferation and differentiation. CSCs can play an important role in carcinogenesis. Many therapeutic strategies currently focus on ablating the subpopulation of CSCs using different approaches such as the overcoming of CSC resistance mechanisms or targeting key molecular pathways controlling these cells. Although these therapeutic strategies have few reported side effects, new strategies are still needed. In this chapter, we describe accumulated data on the stem cell concept of cancerogenesis, how dysregulation of stem cell self-renewal affects cancer transformation, and the roles of CSCs in cancer therapy. We also discuss how improving our current understanding of the biology, behavior, and environment of CSCs can help in advancing their applications in cancer therapies, and devising more effective therapeutic strategies and approaches for cancer. Title of the host publication: Stem cells for cancer and genetic disease treatment. ed. Series: Stem Cells in Clinical Applications

AB - Cancer is currently a major health problem that impacts human life worldwide. Several studies support the concept of stem cells in cancerogenesis. The cancer stem cell (CSC) population is tumorigenic and displays characteristic markers and properties of stem cells, including self- renewal/proliferation and differentiation. CSCs can play an important role in carcinogenesis. Many therapeutic strategies currently focus on ablating the subpopulation of CSCs using different approaches such as the overcoming of CSC resistance mechanisms or targeting key molecular pathways controlling these cells. Although these therapeutic strategies have few reported side effects, new strategies are still needed. In this chapter, we describe accumulated data on the stem cell concept of cancerogenesis, how dysregulation of stem cell self-renewal affects cancer transformation, and the roles of CSCs in cancer therapy. We also discuss how improving our current understanding of the biology, behavior, and environment of CSCs can help in advancing their applications in cancer therapies, and devising more effective therapeutic strategies and approaches for cancer. Title of the host publication: Stem cells for cancer and genetic disease treatment. ed. Series: Stem Cells in Clinical Applications

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ER -

Cancer stem cells and their therapeutic applications [Book]

Abstract

Publication series

Bibliographical note

UN SDGs

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Cite this