Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks. CancerGD includes different screen types (siRNA, shRNA, CRISPR), and we describe a simple format for submitting new datasets.
Bibliographical noteCopyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
- Cell Line, Tumor
- Clustered Regularly Interspaced Short Palindromic Repeats
- Datasets as Topic
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Genetic Testing
- Health Resources
- Precision Medicine
- RNA, Small Interfering/genetics
- Systems Integration