Abstract
Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks. CancerGD includes different screen types (siRNA, shRNA, CRISPR), and we describe a simple format for submitting new datasets.
| Original language | English |
|---|---|
| Pages (from-to) | 82-86.e3 |
| Journal | Cell systems |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 12 Jul 2017 |
| Externally published | Yes |
Bibliographical note
Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.Keywords
- Cell Line, Tumor
- Clustered Regularly Interspaced Short Palindromic Repeats
- Datasets as Topic
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Genetic Testing
- Genomics
- Genotype
- Health Resources
- Humans
- Neoplasms/genetics
- Precision Medicine
- RNA, Small Interfering/genetics
- Software
- Systems Integration
Access to Document
- CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer
Copyright 2020 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.