CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer

Stephen Bridgett; James Campbell; Christopher J Lord; Colm J Ryan

doi:10.1016/j.cels.2017.06.002

CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer

Stephen Bridgett
, James Campbell
, Christopher J Lord
, Colm J Ryan

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

45 Downloads (Pure)

Abstract

Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks. CancerGD includes different screen types (siRNA, shRNA, CRISPR), and we describe a simple format for submitting new datasets.

Original language	English
Pages (from-to)	82-86.e3
Journal	Cell systems
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/j.cels.2017.06.002
Publication status	Published - 12 Jul 2017
Externally published	Yes

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cell Line, Tumor
Clustered Regularly Interspaced Short Palindromic Repeats
Datasets as Topic
Gene Expression Profiling
Genetic Predisposition to Disease
Genetic Testing
Genomics
Genotype
Health Resources
Humans
Neoplasms/genetics
Precision Medicine
RNA, Small Interfering/genetics
Software
Systems Integration

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10.1016/j.cels.2017.06.002Licence: CC BY

CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer
Copyright 2020 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.8 MBLicence: CC BY

Cite this

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title = "CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer",

abstract = "Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks. CancerGD includes different screen types (siRNA, shRNA, CRISPR), and we describe a simple format for submitting new datasets.",

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author = "Stephen Bridgett and James Campbell and Lord, \{Christopher J\} and Ryan, \{Colm J\}",

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doi = "10.1016/j.cels.2017.06.002",

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AU - Lord, Christopher J

AU - Ryan, Colm J

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KW - Clustered Regularly Interspaced Short Palindromic Repeats

KW - Datasets as Topic

KW - Gene Expression Profiling

KW - Genetic Predisposition to Disease

KW - Genetic Testing

KW - Genomics

KW - Genotype

KW - Health Resources

KW - Humans

KW - Neoplasms/genetics

KW - Precision Medicine

KW - RNA, Small Interfering/genetics

KW - Software

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DO - 10.1016/j.cels.2017.06.002

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CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer

Abstract

Bibliographical note

UN SDGs

Keywords

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