TY - JOUR
T1 - Candidate gene analysis of asthma in population of Arab descent: A case-control study in Jordan
AU - Almomani, Basima A.
AU - Al-Eitan, Laith N.
AU - Samrah, Shaher M.
AU - Al-Quasmi, Mohammed N.
AU - McKnight, Amy J.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Aim: To evaluate whether SNPs (n = 15) in ten candidate genes (ADRB2, ADH5, ARGI, CRHR1, STIP1, LTA4H, LTC4S, ALOX5, ABCC1 and OATP2B1) are associated with asthma in Jordanian population of Arab descent. Methods: A case–control study included 245 adult asthmatics and 249 controls. Results: Significant genetic association was identified at the rs2236647 (T/C) SNP in STIP1 and risk of asthma (p < 0.001). The C allele and CC genotype of this SNP were significantly higher in asthmatics compared with controls. The rs1141370 SNP (Val34Met) in ADRB2 is not polymorphic in our cohort. Conclusion: The rs2236647 SNP could act as a reliable tool to identify individuals at risk of developing asthma and provision of early intervention in population of Arab descent.
AB - Aim: To evaluate whether SNPs (n = 15) in ten candidate genes (ADRB2, ADH5, ARGI, CRHR1, STIP1, LTA4H, LTC4S, ALOX5, ABCC1 and OATP2B1) are associated with asthma in Jordanian population of Arab descent. Methods: A case–control study included 245 adult asthmatics and 249 controls. Results: Significant genetic association was identified at the rs2236647 (T/C) SNP in STIP1 and risk of asthma (p < 0.001). The C allele and CC genotype of this SNP were significantly higher in asthmatics compared with controls. The rs1141370 SNP (Val34Met) in ADRB2 is not polymorphic in our cohort. Conclusion: The rs2236647 SNP could act as a reliable tool to identify individuals at risk of developing asthma and provision of early intervention in population of Arab descent.
U2 - 10.2217/pme-2016-0059
DO - 10.2217/pme-2016-0059
M3 - Article
VL - 14
SP - 51
EP - 61
JO - PERSONALIZED MEDICINE
JF - PERSONALIZED MEDICINE
SN - 1741-0541
IS - 1
ER -