Carbohydrate intake, glycemic index and prostate cancer risk

Adriana C Vidal, Christina D Williams, Emma H Allott, Lauren E Howard, Delores J Grant, Megan McPhail, Katharine N Sourbeer, Lin Pao Hwa, Paolo Boffetta, Cathrine Hoyo, Stephen J Freedland

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


BACKGROUND: Reported associations between dietary carbohydrate and prostate cancer (PC) risk are poorly characterized by race.

METHODS: We analyzed the association between carbohydrate intake, glycemic index (GI), and PC risk in a study of white (N = 262) and black (N = 168) veterans at the Durham VA Hospital. Cases were 156 men with biopsy-confirmed PC and controls (N = 274) had a PSA test but were not recommended for biopsy. Diet was assessed before biopsy with a self-administered food frequency questionnaire. Logistic regression models were used to estimate PC risk.

RESULTS: In multivariable analyzes, higher carbohydrate intake, measured as percent of energy from carbohydrates, was associated with reduced PC risk (3rd vs. 1st tertile, OR = 0.41, 95% CI 0.21-0.81, P = 0.010), though this only reached significance in white men (p-trend = 0.029). GI was unrelated to PC risk among all men, but suggestively linked with reduced PC risk in white men (p-trend = 0.066) and increased PC risk in black men (p-trend = 0.172), however, the associations were not significant. Fiber intake was not associated with PC risk (all p-trends > 0.55). Higher carbohydrate intake was associated with reduced risk of high-grade (p-trend = 0.016), but not low-grade PC (p-trend = 0.593).

CONCLUSION: Higher carbohydrate intake may be associated with reduced risk of overall and high-grade PC. Future larger studies are needed to confirm these findings.

Original languageEnglish
Pages (from-to)430-439
Issue number4
Early online date21 Nov 2014
Publication statusPublished - 01 Mar 2015


  • African Continental Ancestry Group
  • Aged
  • Case-Control Studies
  • Diet
  • Dietary Carbohydrates/administration & dosage
  • European Continental Ancestry Group
  • Glycemic Index
  • Humans
  • Male
  • Middle Aged
  • Prostatic Neoplasms/etiology
  • Risk
  • Surveys and Questionnaires

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