Carbon nanomaterials as electrochemical sensors for theophylline: a review

Laurencia Gabrielle Sutanto; Syarifa Sabilla; Brasstira Yuva Wardhana; Anggi Ramadani; Anis Puspita Sari; Qonita Kurnia Anjani; Wan Jeffrey Basirun; Tahta Amrillah; Ilma Amalina; Prastika Krisma Jiwanti

doi:10.1039/d4ra03585b

Carbon nanomaterials as electrochemical sensors for theophylline: a review

Laurencia Gabrielle Sutanto, Syarifa Sabilla, Brasstira Yuva Wardhana, Anggi Ramadani, Anis Puspita Sari, Qonita Kurnia Anjani, Wan Jeffrey Basirun, Tahta Amrillah, Ilma Amalina, Prastika Krisma Jiwanti^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

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Abstract

Theophylline (TP) is a methylxanthine derivative, which serves as a valuable compound in treating respiratory disorders and acts as a bronchodilator agent. However, TP has a limited therapeutic range (20–100 μmol L−1), demanding precise monitoring to prevent potential drug toxicity even with slight level fluctuations during treatment. Thus, to overcome this limitation, electrochemical methods have been extensively used due to their efficacy in achieving sensitivity, selectivity, and accuracy. In the context of electrochemical sensors, nanocarbon-based materials have gained widespread recognition for their extensive applications. Therefore, this review aims to explore the latest advancements in carbon-based electrodes particularly used for the precise determination of TP through electrochemical methods. The results are expected to provide insights into the profound significance of the methods in enhancing the accuracy and sensitivity for the detection of TP.

Original language	English
Pages (from-to)	28927-28942
Number of pages	16
Journal	RSC Advances
Volume	14
Issue number	39
DOIs	https://doi.org/10.1039/d4ra03585b
Publication status	Published - 11 Sept 2024

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10.1039/d4ra03585bLicence: CC BY-NC

Carbon nanomaterials as electrochemical sensors for theophylline: a review
Copyright 2024 the authors. This is an open access Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction for non-commercial purposes, provided the author and source are cited.
Final published version, 2.99 MBLicence: CC BY-NC

Cite this

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title = "Carbon nanomaterials as electrochemical sensors for theophylline: a review",

abstract = "Theophylline (TP) is a methylxanthine derivative, which serves as a valuable compound in treating respiratory disorders and acts as a bronchodilator agent. However, TP has a limited therapeutic range (20–100 μmol L−1), demanding precise monitoring to prevent potential drug toxicity even with slight level fluctuations during treatment. Thus, to overcome this limitation, electrochemical methods have been extensively used due to their efficacy in achieving sensitivity, selectivity, and accuracy. In the context of electrochemical sensors, nanocarbon-based materials have gained widespread recognition for their extensive applications. Therefore, this review aims to explore the latest advancements in carbon-based electrodes particularly used for the precise determination of TP through electrochemical methods. The results are expected to provide insights into the profound significance of the methods in enhancing the accuracy and sensitivity for the detection of TP.",

author = "{Gabrielle Sutanto}, Laurencia and Syarifa Sabilla and Wardhana, {Brasstira Yuva} and Anggi Ramadani and Sari, {Anis Puspita} and Anjani, {Qonita Kurnia} and Basirun, {Wan Jeffrey} and Tahta Amrillah and Ilma Amalina and Jiwanti, {Prastika Krisma}",

year = "2024",

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doi = "10.1039/d4ra03585b",

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T1 - Carbon nanomaterials as electrochemical sensors for theophylline: a review

AU - Gabrielle Sutanto, Laurencia

AU - Sabilla, Syarifa

AU - Wardhana, Brasstira Yuva

AU - Ramadani, Anggi

AU - Sari, Anis Puspita

AU - Anjani, Qonita Kurnia

AU - Basirun, Wan Jeffrey

AU - Amrillah, Tahta

AU - Amalina, Ilma

AU - Jiwanti, Prastika Krisma

PY - 2024/9/11

Y1 - 2024/9/11

N2 - Theophylline (TP) is a methylxanthine derivative, which serves as a valuable compound in treating respiratory disorders and acts as a bronchodilator agent. However, TP has a limited therapeutic range (20–100 μmol L−1), demanding precise monitoring to prevent potential drug toxicity even with slight level fluctuations during treatment. Thus, to overcome this limitation, electrochemical methods have been extensively used due to their efficacy in achieving sensitivity, selectivity, and accuracy. In the context of electrochemical sensors, nanocarbon-based materials have gained widespread recognition for their extensive applications. Therefore, this review aims to explore the latest advancements in carbon-based electrodes particularly used for the precise determination of TP through electrochemical methods. The results are expected to provide insights into the profound significance of the methods in enhancing the accuracy and sensitivity for the detection of TP.

AB - Theophylline (TP) is a methylxanthine derivative, which serves as a valuable compound in treating respiratory disorders and acts as a bronchodilator agent. However, TP has a limited therapeutic range (20–100 μmol L−1), demanding precise monitoring to prevent potential drug toxicity even with slight level fluctuations during treatment. Thus, to overcome this limitation, electrochemical methods have been extensively used due to their efficacy in achieving sensitivity, selectivity, and accuracy. In the context of electrochemical sensors, nanocarbon-based materials have gained widespread recognition for their extensive applications. Therefore, this review aims to explore the latest advancements in carbon-based electrodes particularly used for the precise determination of TP through electrochemical methods. The results are expected to provide insights into the profound significance of the methods in enhancing the accuracy and sensitivity for the detection of TP.

U2 - 10.1039/d4ra03585b

DO - 10.1039/d4ra03585b

M3 - Review article

SN - 2046-2069

VL - 14

SP - 28927

EP - 28942

JO - RSC Advances

JF - RSC Advances

IS - 39

ER -

Carbon nanomaterials as electrochemical sensors for theophylline: a review

Abstract

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