Carboxypeptidase-mediated metabolism of calcitonin gene-related peptide in human gingival crevicular fluid - a role in periodontal inflammation?

Fionnuala Lundy, A.L. Salmon, Philip Lamey, Christopher Shaw, Gerard Linden

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Background: Metabolism by peptidases plays an important role in modulating the levels of biologically-active neuropeptides. The metabolism of the anti-inflammatory neuropeptide calcitonin gene-related peptide (GCRP), but not the pro-inflammatory neuropeptides substance P (SP) and neurokinin A (NKA) by components of the gingival crevicular fluid (GCF), could potentiate the inflammatory process in periodontitis.
Original languageEnglish
Pages (from-to)499-505
Number of pages7
JournalJournal of Clinical Periodontology
Volume27
Publication statusPublished - 2000

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