CASTING SOLVENT CONTROLLED-RELEASE OF CHLORHEXIDINE FROM ETHYLCELLULOSE FILMS PREPARED BY SOLVENT EVAPORATION

David Jones, N.J. Medlicott

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Chlorhexidine release from ethylcellulose films east from solvents of different dichloromethane/ethanol compositions was studied. Release rate was proportional to the square root of time. Increased ethanol content within the casting solvent significantly enhanced release rate. Release rate and cumulative mass released at different time periods (5, 10, 15 and 25 days) were proportional to the solubility parameter of the casting solvent.
Original languageEnglish
Pages (from-to)257-261
Number of pages5
JournalInternational Journal of Pharmaceutics
Volume114
Publication statusPublished - 1995

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