Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini

Porntip Pinlaor, Natthawut Kaewpitoon, Thewarach Laha, Banchob Sripa, Sasithorn Kaewkes, Maria E Morales, Victoria H Mann, Sandi K Parriott, Sutas Suttiprapa, Mark W Robinson, Joyce To, John P Dalton, Alex Loukas, Paul J Brindley

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

The liver fluke Opisthorchis viverrini is classified as a class I carcinogen due to the association between cholangiocarcinoma and chronic O. viverrini infection. During its feeding activity within the bile duct, the parasite secretes several cathepsin F cysteine proteases that may induce or contribute to the pathologies associated with hepatobiliary abnormalities.
Original languageEnglish
Article numbere398
Pages (from-to)e398
JournalPLoS Neglected Tropical Diseases
Volume3
Issue number3
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Pharmacology, Toxicology and Pharmaceutics(all)

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