Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini

Porntip Pinlaor; Natthawut Kaewpitoon; Thewarach Laha; Banchob Sripa; Sasithorn Kaewkes; Maria E Morales; Victoria H Mann; Sandi K Parriott; Sutas Suttiprapa; Mark W Robinson; Joyce To; John P Dalton; Alex Loukas; Paul J Brindley

doi:10.1371/journal.pntd.0000398

Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini

Porntip Pinlaor, Natthawut Kaewpitoon, Thewarach Laha, Banchob Sripa, Sasithorn Kaewkes, Maria E Morales, Victoria H Mann, Sandi K Parriott, Sutas Suttiprapa, Mark W Robinson, Joyce To, John P Dalton, Alex Loukas, Paul J Brindley

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The liver fluke Opisthorchis viverrini is classified as a class I carcinogen due to the association between cholangiocarcinoma and chronic O. viverrini infection. During its feeding activity within the bile duct, the parasite secretes several cathepsin F cysteine proteases that may induce or contribute to the pathologies associated with hepatobiliary abnormalities.

Original language	English
Article number	e398
Pages (from-to)	e398
Journal	PLoS Neglected Tropical Diseases
Volume	3
Issue number	3
DOIs	https://doi.org/10.1371/journal.pntd.0000398
Publication status	Published - 2009

ASJC Scopus subject areas

Infectious Diseases
Public Health, Environmental and Occupational Health
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1371/journal.pntd.0000398

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Pinlaor, P., Kaewpitoon, N., Laha, T., Sripa, B., Kaewkes, S., Morales, M. E., Mann, V. H., Parriott, S. K., Suttiprapa, S., Robinson, M. W., To, J., Dalton, J. P., Loukas, A., & Brindley, P. J. (2009). Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini. PLoS Neglected Tropical Diseases, 3(3), e398. [e398]. https://doi.org/10.1371/journal.pntd.0000398

Pinlaor, Porntip ; Kaewpitoon, Natthawut ; Laha, Thewarach ; Sripa, Banchob ; Kaewkes, Sasithorn ; Morales, Maria E ; Mann, Victoria H ; Parriott, Sandi K ; Suttiprapa, Sutas ; Robinson, Mark W ; To, Joyce ; Dalton, John P ; Loukas, Alex ; Brindley, Paul J. / Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini. In: PLoS Neglected Tropical Diseases. 2009 ; Vol. 3, No. 3. pp. e398.

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abstract = "The liver fluke Opisthorchis viverrini is classified as a class I carcinogen due to the association between cholangiocarcinoma and chronic O. viverrini infection. During its feeding activity within the bile duct, the parasite secretes several cathepsin F cysteine proteases that may induce or contribute to the pathologies associated with hepatobiliary abnormalities.",

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Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini. / Pinlaor, Porntip; Kaewpitoon, Natthawut; Laha, Thewarach; Sripa, Banchob; Kaewkes, Sasithorn; Morales, Maria E; Mann, Victoria H; Parriott, Sandi K; Suttiprapa, Sutas; Robinson, Mark W; To, Joyce; Dalton, John P; Loukas, Alex; Brindley, Paul J.

In: PLoS Neglected Tropical Diseases, Vol. 3, No. 3, e398, 2009, p. e398.

Research output: Contribution to journal › Article › peer-review

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AU - Kaewkes, Sasithorn

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AU - Parriott, Sandi K

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AB - The liver fluke Opisthorchis viverrini is classified as a class I carcinogen due to the association between cholangiocarcinoma and chronic O. viverrini infection. During its feeding activity within the bile duct, the parasite secretes several cathepsin F cysteine proteases that may induce or contribute to the pathologies associated with hepatobiliary abnormalities.

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DO - 10.1371/journal.pntd.0000398

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