Cathepsin S: therapeutic, diagnostic, and prognostic potential

Richard D. A. Wilkinson, Rich Williams, Christopher J. Scott, Roberta E. Burden

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Cathepsin S is a member of the cysteine cathepsin protease family. It is a lysosomal protease which can promote degradation of damaged or unwanted proteins in the endo-lysosomal pathway. Additionally, it has more specific roles such as MHC class II antigen presentation, where it is important in the degradation of the invariant chain. Unsurprisingly, mis-regulation has implicated cathepsin S in a variety of pathological processes including arthritis, cancer, and cardiovascular disease, where it becomes secreted and can act on extracellular substrates. In comparison to many other cysteine cathepsin family members, cathepsin S has uniquely restricted tissue expression and is more stable at a neutral pH, which supports its involvement and importance in localised disease microenvironments. In this review, we examine the known involvement of cathepsin S in disease, particularly with respect to recent work indicating its role in mediating pain, diabetes, and cystic fibrosis. We provide an overview of current literature with regards cathepsin S as a therapeutic target, as well as its role and potential as a predictive diagnostic and/or prognostic marker in these diseases.

Original languageEnglish
Pages (from-to)867-82
Number of pages16
JournalBiological Chemistry
Volume396
Issue number8
Early online date15 Apr 2015
DOIs
Publication statusPublished - Aug 2015

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