CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression

Nigel Stevenson, M.R. Addley, E.J. Ryan, Caroline Boyd, Helen Carroll, Verica Paunovic, C.A. Bursill, H.C. Miller, K.M. Channon, Angela McClurg, Marilyn Armstrong, Wilson Coulter, D.R. Greaves, James Johnston

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26 Citations (Scopus)

Abstract

The chemokine eotaxin/CCL11 is an important mediator of leukocyte migration, but its effect on inflammatory cytokine signaling has not been explored. In this study, we find that CCL11 induces suppressor of cytokine signaling (SOCS) 1 and SOCS3 expression in murine macrophages, human monocytes, and dendritic cells (DCs). We also discover that CCL11 inhibits GM-CSF-mediated STAT5 activation and IL-4-induced STAT6 activation in a range of hematopoietic cells. This blockade of cytokine signaling by CCL11 results in reduced differentiation and endocytic ability of DCs, implicating CCL11-induced SOCS as mediators of chemotactic inflammatory control. These findings demonstrate cross-talk between chemokine and cytokine responses, suggesting that myeloid cells tracking to the inflammatory site do not differentiate in the presence of this chemokine, revealing another role for SOCS in inflammatory regulation. J. Leukoc. Biol. 85: 289-297; 2009.
Original languageEnglish
Pages (from-to)289-297
Number of pages9
JournalJournal of Leukocyte Biology
Volume85
Issue number2
DOIs
Publication statusPublished - 01 Feb 2009

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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    Stevenson, N., Addley, M. R., Ryan, E. J., Boyd, C., Carroll, H., Paunovic, V., Bursill, C. A., Miller, H. C., Channon, K. M., McClurg, A., Armstrong, M., Coulter, W., Greaves, D. R., & Johnston, J. (2009). CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression. Journal of Leukocyte Biology, 85(2), 289-297. https://doi.org/10.1189/jlb.0708394