CD133 expression predicts for non-response to chemotherapy in colorectal cancer

C.W. Ong; L.G. Kim; H.H. Kong; L.Y. Low; B. Iacopetta; R. Soong; Manuel Salto-Tellez

doi:10.1038/modpathol.2009.181

CD133 expression predicts for non-response to chemotherapy in colorectal cancer

C.W. Ong, L.G. Kim, H.H. Kong, L.Y. Low, B. Iacopetta, R. Soong, Manuel Salto-Tellez

Research output: Contribution to journal › Article › peer-review

151 Citations (Scopus)

Abstract

The cancer stem cell hypothesis may explain why conventional chemotherapies are unable to fully eradicate cancers. In this study, we examined both the prognostic and predictive significance of putative cancer stem cell markers in colorectal cancer. In this study, immunohistochemistry for three candidate cancer stem cell markers (CD133, Oct-4 and Sox-2) and for six other postulated prognostic markers (CK7, CK20, Cox-2, Ki-67, p27 and p53) were performed using tissue microarrays containing 501 primary colorectal cancer cases. Receiver-operating characteristic analysis was used to determine cut-off scores for positive protein expression. Multivariate analysis revealed that positive expression for CD133 and Oct-4 was associated with significantly worse survival in patients treated by surgery alone (P=0.023 and P

Original language	English
Pages (from-to)	450-457
Number of pages	8
Journal	Modern pathology
Volume	23
Issue number	3
DOIs	https://doi.org/10.1038/modpathol.2009.181
Publication status	Published - Mar 2010

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1038/modpathol.2009.181

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title = "CD133 expression predicts for non-response to chemotherapy in colorectal cancer",

abstract = "The cancer stem cell hypothesis may explain why conventional chemotherapies are unable to fully eradicate cancers. In this study, we examined both the prognostic and predictive significance of putative cancer stem cell markers in colorectal cancer. In this study, immunohistochemistry for three candidate cancer stem cell markers (CD133, Oct-4 and Sox-2) and for six other postulated prognostic markers (CK7, CK20, Cox-2, Ki-67, p27 and p53) were performed using tissue microarrays containing 501 primary colorectal cancer cases. Receiver-operating characteristic analysis was used to determine cut-off scores for positive protein expression. Multivariate analysis revealed that positive expression for CD133 and Oct-4 was associated with significantly worse survival in patients treated by surgery alone (P=0.023 and P",

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T1 - CD133 expression predicts for non-response to chemotherapy in colorectal cancer

AU - Ong, C.W.

AU - Kim, L.G.

AU - Kong, H.H.

AU - Low, L.Y.

AU - Iacopetta, B.

AU - Soong, R.

AU - Salto-Tellez, Manuel

PY - 2010/3

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N2 - The cancer stem cell hypothesis may explain why conventional chemotherapies are unable to fully eradicate cancers. In this study, we examined both the prognostic and predictive significance of putative cancer stem cell markers in colorectal cancer. In this study, immunohistochemistry for three candidate cancer stem cell markers (CD133, Oct-4 and Sox-2) and for six other postulated prognostic markers (CK7, CK20, Cox-2, Ki-67, p27 and p53) were performed using tissue microarrays containing 501 primary colorectal cancer cases. Receiver-operating characteristic analysis was used to determine cut-off scores for positive protein expression. Multivariate analysis revealed that positive expression for CD133 and Oct-4 was associated with significantly worse survival in patients treated by surgery alone (P=0.023 and P

AB - The cancer stem cell hypothesis may explain why conventional chemotherapies are unable to fully eradicate cancers. In this study, we examined both the prognostic and predictive significance of putative cancer stem cell markers in colorectal cancer. In this study, immunohistochemistry for three candidate cancer stem cell markers (CD133, Oct-4 and Sox-2) and for six other postulated prognostic markers (CK7, CK20, Cox-2, Ki-67, p27 and p53) were performed using tissue microarrays containing 501 primary colorectal cancer cases. Receiver-operating characteristic analysis was used to determine cut-off scores for positive protein expression. Multivariate analysis revealed that positive expression for CD133 and Oct-4 was associated with significantly worse survival in patients treated by surgery alone (P=0.023 and P

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DO - 10.1038/modpathol.2009.181

M3 - Article

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VL - 23

SP - 450

EP - 457

JO - Modern pathology

JF - Modern pathology

IS - 3

ER -

CD133 expression predicts for non-response to chemotherapy in colorectal cancer

Abstract

ASJC Scopus subject areas

UN SDGs

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