CD133 expression predicts for non-response to chemotherapy in colorectal cancer

C.W. Ong, L.G. Kim, H.H. Kong, L.Y. Low, B. Iacopetta, R. Soong, Manuel Salto-Tellez

Research output: Contribution to journalArticlepeer-review

133 Citations (Scopus)

Abstract

The cancer stem cell hypothesis may explain why conventional chemotherapies are unable to fully eradicate cancers. In this study, we examined both the prognostic and predictive significance of putative cancer stem cell markers in colorectal cancer. In this study, immunohistochemistry for three candidate cancer stem cell markers (CD133, Oct-4 and Sox-2) and for six other postulated prognostic markers (CK7, CK20, Cox-2, Ki-67, p27 and p53) were performed using tissue microarrays containing 501 primary colorectal cancer cases. Receiver-operating characteristic analysis was used to determine cut-off scores for positive protein expression. Multivariate analysis revealed that positive expression for CD133 and Oct-4 was associated with significantly worse survival in patients treated by surgery alone (P=0.023 and P
Original languageEnglish
Pages (from-to)450-457
Number of pages8
JournalModern pathology
Volume23
Issue number3
DOIs
Publication statusPublished - Mar 2010

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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