Cell irradiation experiment using laser driven protons at ultra high dose rate

K. F. Kakolee; D. Doria; S. Kar; S. Lift; M. Zepf; M. Borghesi; D. Kirby; F. Fiorini; S. Green; K. Kirby; J. C. Jeynes; M. Merchant; J. Kavanagh; G. Schettino

Cell irradiation experiment using laser driven protons at ultra high dose rate

K. F. Kakolee^*, D. Doria, S. Kar, S. Lift, M. Zepf, M. Borghesi, D. Kirby, F. Fiorini, S. Green, K. Kirby, J. C. Jeynes, M. Merchant, J. Kavanagh, G. Schettino

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The effect of proton irradiation of biological cells, on timescales orders of magnitude shorter than with conventional accelerators, has been investigated by employing the TARANIS laser at Queen's University. Multiple cell-spots with different doses and proton energies were irradiated at the same time in a single laser shot at dose rates exceeding 109 Gy/sec. The data show a clear dose-dependant lethal effect of laser-driven protons over V-79 cells. A comparison with the survival obtained with an X-Ray standard source has been done and the resulting relative biological effectiveness (RBE) is about 1.3 at 10%.

Original language	English
Title of host publication	38th EPS Conference on Plasma Physics 2011, EPS 2011 - Europhysics Conference Abstracts
Pages	133-136
Number of pages	4
Volume	35 1
Publication status	Published - 01 Dec 2011
Event	38th EPS Conference on Plasma Physics 2011, EPS 2011 - Strasbourg, France Duration: 27 Jun 2011 → 01 Jul 2011

Conference

Conference	38th EPS Conference on Plasma Physics 2011, EPS 2011
Country/Territory	France
City	Strasbourg
Period	27/06/2011 → 01/07/2011

ASJC Scopus subject areas

Nuclear and High Energy Physics

Cite this

Kakolee, K. F., Doria, D., Kar, S., Lift, S., Zepf, M., Borghesi, M., Kirby, D., Fiorini, F., Green, S., Kirby, K., Jeynes, J. C., Merchant, M., Kavanagh, J., & Schettino, G. (2011). Cell irradiation experiment using laser driven protons at ultra high dose rate. In 38th EPS Conference on Plasma Physics 2011, EPS 2011 - Europhysics Conference Abstracts (Vol. 35 1, pp. 133-136)

@inproceedings{9af4a64f461f4d9c875b39c5cbe75026,

title = "Cell irradiation experiment using laser driven protons at ultra high dose rate",

abstract = "The effect of proton irradiation of biological cells, on timescales orders of magnitude shorter than with conventional accelerators, has been investigated by employing the TARANIS laser at Queen's University. Multiple cell-spots with different doses and proton energies were irradiated at the same time in a single laser shot at dose rates exceeding 109 Gy/sec. The data show a clear dose-dependant lethal effect of laser-driven protons over V-79 cells. A comparison with the survival obtained with an X-Ray standard source has been done and the resulting relative biological effectiveness (RBE) is about 1.3 at 10%.",

author = "Kakolee, {K. F.} and D. Doria and S. Kar and S. Lift and M. Zepf and M. Borghesi and D. Kirby and F. Fiorini and S. Green and K. Kirby and Jeynes, {J. C.} and M. Merchant and J. Kavanagh and G. Schettino",

year = "2011",

month = dec,

day = "1",

language = "English",

isbn = "9781618395931",

volume = "35 1",

pages = "133--136",

booktitle = "38th EPS Conference on Plasma Physics 2011, EPS 2011 - Europhysics Conference Abstracts",

note = "38th EPS Conference on Plasma Physics 2011, EPS 2011 ; Conference date: 27-06-2011 Through 01-07-2011",

}

Kakolee, KF, Doria, D, Kar, S, Lift, S, Zepf, M, Borghesi, M, Kirby, D, Fiorini, F, Green, S, Kirby, K, Jeynes, JC, Merchant, M, Kavanagh, J & Schettino, G 2011, Cell irradiation experiment using laser driven protons at ultra high dose rate. in 38th EPS Conference on Plasma Physics 2011, EPS 2011 - Europhysics Conference Abstracts. vol. 35 1, pp. 133-136, 38th EPS Conference on Plasma Physics 2011, EPS 2011, Strasbourg, France, 27/06/2011.

TY - GEN

T1 - Cell irradiation experiment using laser driven protons at ultra high dose rate

AU - Kakolee, K. F.

AU - Doria, D.

AU - Kar, S.

AU - Lift, S.

AU - Zepf, M.

AU - Borghesi, M.

AU - Kirby, D.

AU - Fiorini, F.

AU - Green, S.

AU - Kirby, K.

AU - Jeynes, J. C.

AU - Merchant, M.

AU - Kavanagh, J.

AU - Schettino, G.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - The effect of proton irradiation of biological cells, on timescales orders of magnitude shorter than with conventional accelerators, has been investigated by employing the TARANIS laser at Queen's University. Multiple cell-spots with different doses and proton energies were irradiated at the same time in a single laser shot at dose rates exceeding 109 Gy/sec. The data show a clear dose-dependant lethal effect of laser-driven protons over V-79 cells. A comparison with the survival obtained with an X-Ray standard source has been done and the resulting relative biological effectiveness (RBE) is about 1.3 at 10%.

AB - The effect of proton irradiation of biological cells, on timescales orders of magnitude shorter than with conventional accelerators, has been investigated by employing the TARANIS laser at Queen's University. Multiple cell-spots with different doses and proton energies were irradiated at the same time in a single laser shot at dose rates exceeding 109 Gy/sec. The data show a clear dose-dependant lethal effect of laser-driven protons over V-79 cells. A comparison with the survival obtained with an X-Ray standard source has been done and the resulting relative biological effectiveness (RBE) is about 1.3 at 10%.

UR - http://www.scopus.com/inward/record.url?scp=84867637145&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84867637145

SN - 9781618395931

VL - 35 1

SP - 133

EP - 136

BT - 38th EPS Conference on Plasma Physics 2011, EPS 2011 - Europhysics Conference Abstracts

T2 - 38th EPS Conference on Plasma Physics 2011, EPS 2011

Y2 - 27 June 2011 through 1 July 2011

ER -

Cell irradiation experiment using laser driven protons at ultra high dose rate

Abstract

Conference

ASJC Scopus subject areas

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