Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology

Candy Chuah, Malcolm K. Jones, Melissa L. Burke, Donald P. McManus, Geoffrey N. Gobert*

*Corresponding author for this work

Research output: Contribution to journalReview article

94 Citations (Scopus)

Abstract

In hepatic schistosomiasis, pathology arises when schistosome eggs become lodged in the host liver, evoking an interleukin 4 (IL-4)- and IL-13-mediated dominant CD4+ Th2 immune response. This response leads to the development of granulomas and fibrosis, with eosinophils, neutrophils, macrophages, hepatic stellate cells, and lymphocytes all identified as major cellular contributors to these events. This review outlines the cellular and molecular mechanisms of hepatic schistosomiasis, with an emphasis on the major cellular components and their release of chemokines. The differences between Schistosoma mansoni- and Schistosoma japonicum-induced hepatic granuloma are also discussed. This comprehensive overview of the processes associated with hepatic schistosomiasis may provide new insights into improved treatment for both schistosomiasis and other granulofibrotic diseases. 

Original languageEnglish
Pages (from-to)141-150
JournalTrends in Parasitology
Volume30
Issue number3
Early online date13 Jan 2014
DOIs
Publication statusPublished - Mar 2014

Keywords

  • Chemokine
  • Granuloma
  • Immunopathology
  • Schistosomiasis

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Fingerprint Dive into the research topics of 'Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology'. Together they form a unique fingerprint.

Cite this