Cellular and molecular basis of therapeutic approaches to breast cancer

Mohamed El-Tanani, Arwa Omar Al Khatib, Belal O Al-Najjar, Ashok K Shakya, Yahia El-Tanani, Yin-Fai Lee, Ángel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Alaa A Aljabali, Rohit Goyal, Poonam Negi, Marzieh Ramezani Farani, Maryam Moradi Binabaj, Amir Gholami, Maryam Moradi Binabaj, Nitin B Charbe, Murtaza M Tambuwala

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Abstract

In recent decades, there has been a significant amount of research into breast cancer, with some important breakthroughs in the treatment of both primary and metastatic breast cancers. It's a well-known fact that treating breast cancer is still a challenging endeavour even though physicians have a fantastic toolset of the latest treatment options at their disposal. Due to limitations of current clinical treatment options, traditional chemotherapeutic drugs, and surgical options are still required to address this condition. In recent years, there have been several developments resulting in a wide range of treatment options. This review article discusses the cellular and molecular foundation of chemotherapeutic drugs, endocrine system-based treatments, biological therapies, gene therapy, and innovative techniques for treating breast cancer.
Original languageEnglish
Article number110492
JournalCellular signalling
Volume101
Early online date02 Nov 2022
DOIs
Publication statusPublished - Jan 2023

Keywords

  • Gene therapy
  • Biologicals
  • Cellular signaling
  • Breast cancer
  • Therapeutics

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