Central and peripheral myeloid-derived suppressor cell-like cells are closely related to the clinical severity of multiple sclerosis

María Cristina Ortega, Rafael Lebrón-Galán, Isabel Machín-Díaz, Michelle Naughton, Inmaculada Pérez-Molina, Jennifer García-Arocha, Jose Manuel Garcia-Dominguez, Haydee Goicoechea-Briceño, Virginia Vila-Del Sol, Víctor Quintanero-Casero, Rosa García-Montero, Victoria Galán, Leticia Calahorra, Celia Camacho-Toledano, María Luisa Martínez-Ginés, Denise C Fitzgerald, Diego Clemente

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Multiple sclerosis (MS) is a highly heterogeneous demyelinating disease of the central nervous system (CNS) that needs for reliable biomarkers to foresee disease severity. Recently, myeloid-derived suppressor cells (MDSCs) have emerged as an immune cell population with an important role in MS. The monocytic-MDSCs (M-MDSCs) share the phenotype with Ly-6C -cells in the MS animal model, experimental autoimmune encephalomyelitis (EAE), and have been retrospectively related to the severity of the clinical course in the EAE. However, no data are available about the presence of M-MDSCs in the CNS of MS patients or its relation with the future disease aggressiveness. In this work, we show for the first time cells exhibiting all the bona-fide phenotypical markers of M-MDSCs associated with MS lesions, whose abundance in these areas appears to be directly correlated with longer disease duration in primary progressive MS patients. Moreover, we show that blood immunosuppressive Ly-6C -cells are strongly related to the future severity of EAE disease course. We found that a higher abundance of Ly-6C -cells at the onset of the EAE clinical course is associated with a milder disease course and less tissue damage. In parallel, we determined that the abundance of M-MDSCs in blood samples from untreated MS patients at their first relapse is inversely correlated with the Expanded Disability Status Scale (EDSS) at baseline and after a 1-year follow-up. In summary, our data point to M-MDSC load as a factor to be considered for future studies focused on the prediction of disease severity in EAE and MS.
Original languageEnglish
JournalActa Neuropathologica
Early online date27 May 2023
DOIs
Publication statusEarly online date - 27 May 2023

Keywords

  • EAE
  • Biomarker
  • Myelin
  • Histopathology
  • Regulatory cells
  • PBMCs

Fingerprint

Dive into the research topics of 'Central and peripheral myeloid-derived suppressor cell-like cells are closely related to the clinical severity of multiple sclerosis'. Together they form a unique fingerprint.

Cite this