Challenges in exosome nanovesicle-based drug delivery and diagnostics

Vaishali Makwana, Nimeet Desai, Dhwani Rana, Derajram Benival, Lalitkumar K. Vora

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Exosomes are small extracellular vesicles ranging from 30 to 150nm in diameter. They facilitate intricate cell-to-cell communication and reflect the physiological and pathological states of their originating cells. This capability positions them as ideal candidates for noninvasive diagnostic tools and targeted drug delivery systems. Exosomes can be engineered to enhance their natural propensity for tissue targeting, potentially transforming the delivery of therapeutics by protecting drugs from enzymatic degradation and minimizing immune reactions. Additionally, their role in conveying molecular information offers a window into cellular functions, enabling early disease detection and monitoring through liquid biopsies. However, the clinical translation and commercialization of exosome-based applications face significant challenges. These include the scalability of production methods, the standardization of isolation and purification protocols, and the establishment of regulatory frameworks. Addressing these challenges necessitates advancements in technological platforms, cross-disciplinary collaboration, and innovation in regulatory strategies. This manuscript comprehensively explores these challenges and outlines potential pathways forward, emphasizing the need for a coordinated effort to harness the clinical benefits of exosomes in medicine.

Original languageEnglish
Title of host publicationExosome communication. Advances in research and therapeutics for health and disease
EditorsDalapathi Gugulothu, Dharmendra Kumar Khatri, Lalitkumar K. Vora, William C. Cho
PublisherElsevier Inc.
Chapter8
Pages203-252
Number of pages50
ISBN (Electronic)9780443290527
ISBN (Print)9780443290534
DOIs
Publication statusPublished - 29 Nov 2024

Bibliographical note

Publisher Copyright:
© 2025 Elsevier Inc. All rights reserved.

Keywords

  • Biomarkers
  • Drug delivery
  • Exosome therapeutics
  • Extracellular vesicles
  • Noninvasive diagnostics

ASJC Scopus subject areas

  • General Medicine
  • General Pharmacology, Toxicology and Pharmaceutics

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