Changes in Bone Marrow Fat upon Dietary-Induced Weight Loss

Manuela Spurny; Yixin Jiang; Solomon A Sowah; Ruth Schübel; Tobias Nonnenmacher; Robert Bertheau; Romy Kirsten; Theron Johnson; Jens Hillengass; Christopher L Schlett; Oyunbileg von Stackelberg; Cornelia M Ulrich; Rudolf Kaaks; Hans-Ulrich Kauczor; Tilman Kühn; Johanna Nattenmüller

doi:10.3390/nu12051509

Changes in Bone Marrow Fat upon Dietary-Induced Weight Loss

Manuela Spurny, Yixin Jiang, Solomon A Sowah, Ruth Schübel, Tobias Nonnenmacher, Robert Bertheau, Romy Kirsten, Theron Johnson, Jens Hillengass, Christopher L Schlett, Oyunbileg von Stackelberg, Cornelia M Ulrich, Rudolf Kaaks, Hans-Ulrich Kauczor, Tilman Kühn, Johanna Nattenmüller

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Abstract

BACKGROUND: Bone marrow fat is implicated in metabolism, bone health and haematological diseases. Thus, this study aims to analyse the impact of moderate weight loss on bone marrow fat content (BMFC) in obese, healthy individuals.

METHODS: Data of the HELENA-Trial (Healthy nutrition and energy restriction as cancer prevention strategies: a randomized controlled intervention trial), a randomized controlled trial (RCT) among 137 non-smoking, overweight or obese participants, were analysed to quantify the Magnetic Resonance Imaging (MRI)-derived BMFC at baseline, after a 12-week dietary intervention phase, and after a 50-week follow-up. The study cohort was classified into quartiles based on changes in body weight between baseline and week 12. Changes in BMFC in respect of weight loss were analysed by linear mixed models. Spearman's coefficients were used to assess correlations between anthropometric parameters, blood biochemical markers, blood cells and BMFC.

RESULTS: Relative changes in BMFC from baseline to week 12 were 0.0 ± 0.2%, -3.2 ± 0.1%, -6.1 ± 0.2% and -11.5 ± 0.6% for Q1 to Q4. Across all four quartiles and for the two-group comparison, Q1 versus Q4, there was a significant difference (p < 0.05) for changes in BMFC. BMFC was not associated with blood cell counts and showed only weaker correlations (<0.3) with metabolic biomarkers.

CONCLUSION: Weight loss is associated with a decrease of BMFC. However, BMFC showed no stronger associations with inflammatory and metabolic biomarkers.

Original language	English
Journal	Nutrients
Volume	12
Issue number	5
DOIs	https://doi.org/10.3390/nu12051509
Publication status	Published - 22 May 2020
Externally published	Yes

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Changes in Bone Marrow Fat upon Dietary-Induced Weight Loss
Copyright 2020 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 795 KBLicence: CC BY

Cite this

@article{502fa47f03864c8b89ddf83898ebef21,

title = "Changes in Bone Marrow Fat upon Dietary-Induced Weight Loss",

abstract = "BACKGROUND: Bone marrow fat is implicated in metabolism, bone health and haematological diseases. Thus, this study aims to analyse the impact of moderate weight loss on bone marrow fat content (BMFC) in obese, healthy individuals.METHODS: Data of the HELENA-Trial (Healthy nutrition and energy restriction as cancer prevention strategies: a randomized controlled intervention trial), a randomized controlled trial (RCT) among 137 non-smoking, overweight or obese participants, were analysed to quantify the Magnetic Resonance Imaging (MRI)-derived BMFC at baseline, after a 12-week dietary intervention phase, and after a 50-week follow-up. The study cohort was classified into quartiles based on changes in body weight between baseline and week 12. Changes in BMFC in respect of weight loss were analysed by linear mixed models. Spearman's coefficients were used to assess correlations between anthropometric parameters, blood biochemical markers, blood cells and BMFC.RESULTS: Relative changes in BMFC from baseline to week 12 were 0.0 ± 0.2%, -3.2 ± 0.1%, -6.1 ± 0.2% and -11.5 ± 0.6% for Q1 to Q4. Across all four quartiles and for the two-group comparison, Q1 versus Q4, there was a significant difference (p < 0.05) for changes in BMFC. BMFC was not associated with blood cell counts and showed only weaker correlations (<0.3) with metabolic biomarkers.CONCLUSION: Weight loss is associated with a decrease of BMFC. However, BMFC showed no stronger associations with inflammatory and metabolic biomarkers.",

author = "Manuela Spurny and Yixin Jiang and Sowah, {Solomon A} and Ruth Sch{\"u}bel and Tobias Nonnenmacher and Robert Bertheau and Romy Kirsten and Theron Johnson and Jens Hillengass and Schlett, {Christopher L} and {von Stackelberg}, Oyunbileg and Ulrich, {Cornelia M} and Rudolf Kaaks and Hans-Ulrich Kauczor and Tilman K{\"u}hn and Johanna Nattenm{\"u}ller",

year = "2020",

month = may,

day = "22",

doi = "10.3390/nu12051509",

language = "English",

volume = "12",

journal = "Nutrients",

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publisher = "MDPI",

number = "5",

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TY - JOUR

T1 - Changes in Bone Marrow Fat upon Dietary-Induced Weight Loss

AU - Spurny, Manuela

AU - Jiang, Yixin

AU - Sowah, Solomon A

AU - Schübel, Ruth

AU - Nonnenmacher, Tobias

AU - Bertheau, Robert

AU - Kirsten, Romy

AU - Johnson, Theron

AU - Hillengass, Jens

AU - Schlett, Christopher L

AU - von Stackelberg, Oyunbileg

AU - Ulrich, Cornelia M

AU - Kaaks, Rudolf

AU - Kauczor, Hans-Ulrich

AU - Kühn, Tilman

AU - Nattenmüller, Johanna

PY - 2020/5/22

Y1 - 2020/5/22

N2 - BACKGROUND: Bone marrow fat is implicated in metabolism, bone health and haematological diseases. Thus, this study aims to analyse the impact of moderate weight loss on bone marrow fat content (BMFC) in obese, healthy individuals.METHODS: Data of the HELENA-Trial (Healthy nutrition and energy restriction as cancer prevention strategies: a randomized controlled intervention trial), a randomized controlled trial (RCT) among 137 non-smoking, overweight or obese participants, were analysed to quantify the Magnetic Resonance Imaging (MRI)-derived BMFC at baseline, after a 12-week dietary intervention phase, and after a 50-week follow-up. The study cohort was classified into quartiles based on changes in body weight between baseline and week 12. Changes in BMFC in respect of weight loss were analysed by linear mixed models. Spearman's coefficients were used to assess correlations between anthropometric parameters, blood biochemical markers, blood cells and BMFC.RESULTS: Relative changes in BMFC from baseline to week 12 were 0.0 ± 0.2%, -3.2 ± 0.1%, -6.1 ± 0.2% and -11.5 ± 0.6% for Q1 to Q4. Across all four quartiles and for the two-group comparison, Q1 versus Q4, there was a significant difference (p < 0.05) for changes in BMFC. BMFC was not associated with blood cell counts and showed only weaker correlations (<0.3) with metabolic biomarkers.CONCLUSION: Weight loss is associated with a decrease of BMFC. However, BMFC showed no stronger associations with inflammatory and metabolic biomarkers.

AB - BACKGROUND: Bone marrow fat is implicated in metabolism, bone health and haematological diseases. Thus, this study aims to analyse the impact of moderate weight loss on bone marrow fat content (BMFC) in obese, healthy individuals.METHODS: Data of the HELENA-Trial (Healthy nutrition and energy restriction as cancer prevention strategies: a randomized controlled intervention trial), a randomized controlled trial (RCT) among 137 non-smoking, overweight or obese participants, were analysed to quantify the Magnetic Resonance Imaging (MRI)-derived BMFC at baseline, after a 12-week dietary intervention phase, and after a 50-week follow-up. The study cohort was classified into quartiles based on changes in body weight between baseline and week 12. Changes in BMFC in respect of weight loss were analysed by linear mixed models. Spearman's coefficients were used to assess correlations between anthropometric parameters, blood biochemical markers, blood cells and BMFC.RESULTS: Relative changes in BMFC from baseline to week 12 were 0.0 ± 0.2%, -3.2 ± 0.1%, -6.1 ± 0.2% and -11.5 ± 0.6% for Q1 to Q4. Across all four quartiles and for the two-group comparison, Q1 versus Q4, there was a significant difference (p < 0.05) for changes in BMFC. BMFC was not associated with blood cell counts and showed only weaker correlations (<0.3) with metabolic biomarkers.CONCLUSION: Weight loss is associated with a decrease of BMFC. However, BMFC showed no stronger associations with inflammatory and metabolic biomarkers.

U2 - 10.3390/nu12051509

DO - 10.3390/nu12051509

M3 - Article

C2 - 32455947

SN - 2072-6643

VL - 12

JO - Nutrients

JF - Nutrients

IS - 5

ER -

Changes in Bone Marrow Fat upon Dietary-Induced Weight Loss

Abstract

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