Growth and metabolism of fungi can be curtailed by chaotropic solutes and hydrophobic substances, both of which can weaken or inhibit non-covalent interactions within and between macromolecular systems. Here we explore the potential to utilize the fungistatic and fungicidal activities of such stressors as the basis for commercial formulations. A method was developed for the quantification of chaotropicity, which can be used for chemically diverse substances, in order elucidate roles of chaotropicity and hydrophobicity in microbial ecology (both of which are sufficiently potent to limit the Earth’s microbial biosphere). A large number of naturally occurring substances act as chaotropic or hydrophobic stressors including aliphatic alcohols, salts such as MgCl2, aromatics such as phenol, and hydrocarbons such as hexane and octene. We suggest that these stress parameters provide the (hitherto unidentified) modes-of-action for some extant antifungal products. The findings are discussed in relation to the development of a new generation of antifungals.
|Title of host publication||Modern Fungicides and Antifungal Compounds VII: Proceedings of the 17th International Reinhardsbrunn Symposium April 21 -25, 2013, Friedrichroda, Germany|
|Place of Publication||Braunschweig|
|Publisher||Deutsche Phytomedizinische Gesellschaft|
|Number of pages||8|
|Publication status||Published - 2014|
Cray, J. A., Bhaganna, P., Singhal, R. S., Patil, S. V., Saha, D., Chakraborty, D., Iwaguchi , S., Timson, D. J., & Hallsworth, J. E. (2014). Chaotropic and hydrophobic stress mechanisms of antifungal substances. In Modern Fungicides and Antifungal Compounds VII: Proceedings of the 17th International Reinhardsbrunn Symposium April 21 -25, 2013, Friedrichroda, Germany (Vol. VII, pp. 73-80). Deutsche Phytomedizinische Gesellschaft. http://dpg.phytomedizin.org/fileadmin/daten/04_Verlag/02_SP/05_Reinhard/0294-sp-2014-Reinh-1.pdf