Chaotropic and hydrophobic stress mechanisms of antifungal substances

J. A. Cray; P. Bhaganna; R. S.  Singhal; S. V. Patil; D Saha; D Chakraborty; S Iwaguchi; D. J. Timson; J. E. Hallsworth

Chaotropic and hydrophobic stress mechanisms of antifungal substances

J. A. Cray, P. Bhaganna, R. S. Singhal, S. V. Patil, D Saha, D Chakraborty, S Iwaguchi , D. J. Timson, J. E. Hallsworth

School of Biological Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Growth and metabolism of fungi can be curtailed by chaotropic solutes and hydrophobic substances, both of which can weaken or inhibit non-covalent interactions within and between macromolecular systems. Here we explore the potential to utilize the fungistatic and fungicidal activities of such stressors as the basis for commercial formulations. A method was developed for the quantification of chaotropicity, which can be used for chemically diverse substances, in order elucidate roles of chaotropicity and hydrophobicity in microbial ecology (both of which are sufficiently potent to limit the Earth’s microbial biosphere). A large number of naturally occurring substances act as chaotropic or hydrophobic stressors including aliphatic alcohols, salts such as MgCl2, aromatics such as phenol, and hydrocarbons such as hexane and octene. We suggest that these stress parameters provide the (hitherto unidentified) modes-of-action for some extant antifungal products. The findings are discussed in relation to the development of a new generation of antifungals.

Original language	English
Title of host publication	Modern Fungicides and Antifungal Compounds VII: Proceedings of the 17th International Reinhardsbrunn Symposium April 21 -25, 2013, Friedrichroda, Germany
Place of Publication	Braunschweig
Publisher	Deutsche Phytomedizinische Gesellschaft
Pages	73-80
Number of pages	8
Volume	VII
ISBN (Print)	9783941261136
Publication status	Published - 2014

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Cray, J. A., Bhaganna, P., Singhal, R. S., Patil, S. V., Saha, D., Chakraborty, D., Iwaguchi , S., Timson, D. J., & Hallsworth, J. E. (2014). Chaotropic and hydrophobic stress mechanisms of antifungal substances. In Modern Fungicides and Antifungal Compounds VII: Proceedings of the 17th International Reinhardsbrunn Symposium April 21 -25, 2013, Friedrichroda, Germany (Vol. VII, pp. 73-80). Deutsche Phytomedizinische Gesellschaft. http://dpg.phytomedizin.org/fileadmin/daten/04_Verlag/02_SP/05_Reinhard/0294-sp-2014-Reinh-1.pdf

Cray, J. A. ; Bhaganna, P. ; Singhal, R. S. ; Patil, S. V. ; Saha, D ; Chakraborty, D ; Iwaguchi , S ; Timson, D. J. ; Hallsworth, J. E. / Chaotropic and hydrophobic stress mechanisms of antifungal substances. Modern Fungicides and Antifungal Compounds VII: Proceedings of the 17th International Reinhardsbrunn Symposium April 21 -25, 2013, Friedrichroda, Germany. Vol. VII Braunschweig : Deutsche Phytomedizinische Gesellschaft, 2014. pp. 73-80

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title = "Chaotropic and hydrophobic stress mechanisms of antifungal substances",

abstract = "Growth and metabolism of fungi can be curtailed by chaotropic solutes and hydrophobic substances, both of which can weaken or inhibit non-covalent interactions within and between macromolecular systems. Here we explore the potential to utilize the fungistatic and fungicidal activities of such stressors as the basis for commercial formulations. A method was developed for the quantification of chaotropicity, which can be used for chemically diverse substances, in order elucidate roles of chaotropicity and hydrophobicity in microbial ecology (both of which are sufficiently potent to limit the Earth{\textquoteright}s microbial biosphere). A large number of naturally occurring substances act as chaotropic or hydrophobic stressors including aliphatic alcohols, salts such as MgCl2, aromatics such as phenol, and hydrocarbons such as hexane and octene. We suggest that these stress parameters provide the (hitherto unidentified) modes-of-action for some extant antifungal products. The findings are discussed in relation to the development of a new generation of antifungals. ",

author = "Cray, {J. A.} and P. Bhaganna and Singhal, {R. S.} and Patil, {S. V.} and D Saha and D Chakraborty and S Iwaguchi and Timson, {D. J.} and Hallsworth, {J. E.}",

year = "2014",

language = "English",

isbn = "9783941261136",

volume = "VII",

pages = "73--80",

booktitle = "Modern Fungicides and Antifungal Compounds VII: Proceedings of the 17th International Reinhardsbrunn Symposium April 21 -25, 2013, Friedrichroda, Germany",

publisher = "Deutsche Phytomedizinische Gesellschaft",

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Cray, JA, Bhaganna, P, Singhal, RS, Patil, SV, Saha, D, Chakraborty, D, Iwaguchi , S, Timson, DJ & Hallsworth, JE 2014, Chaotropic and hydrophobic stress mechanisms of antifungal substances. in Modern Fungicides and Antifungal Compounds VII: Proceedings of the 17th International Reinhardsbrunn Symposium April 21 -25, 2013, Friedrichroda, Germany. vol. VII, Deutsche Phytomedizinische Gesellschaft, Braunschweig, pp. 73-80. <http://dpg.phytomedizin.org/fileadmin/daten/04_Verlag/02_SP/05_Reinhard/0294-sp-2014-Reinh-1.pdf>

Chaotropic and hydrophobic stress mechanisms of antifungal substances. / Cray, J. A.; Bhaganna, P.; Singhal, R. S. ; Patil, S. V.; Saha, D; Chakraborty, D; Iwaguchi , S; Timson, D. J.; Hallsworth, J. E.

Modern Fungicides and Antifungal Compounds VII: Proceedings of the 17th International Reinhardsbrunn Symposium April 21 -25, 2013, Friedrichroda, Germany. Vol. VII Braunschweig : Deutsche Phytomedizinische Gesellschaft, 2014. p. 73-80.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

TY - CHAP

T1 - Chaotropic and hydrophobic stress mechanisms of antifungal substances

AU - Cray, J. A.

AU - Bhaganna, P.

AU - Singhal, R. S.

AU - Patil, S. V.

AU - Saha, D

AU - Chakraborty, D

AU - Iwaguchi , S

AU - Timson, D. J.

AU - Hallsworth, J. E.

PY - 2014

Y1 - 2014

N2 - Growth and metabolism of fungi can be curtailed by chaotropic solutes and hydrophobic substances, both of which can weaken or inhibit non-covalent interactions within and between macromolecular systems. Here we explore the potential to utilize the fungistatic and fungicidal activities of such stressors as the basis for commercial formulations. A method was developed for the quantification of chaotropicity, which can be used for chemically diverse substances, in order elucidate roles of chaotropicity and hydrophobicity in microbial ecology (both of which are sufficiently potent to limit the Earth’s microbial biosphere). A large number of naturally occurring substances act as chaotropic or hydrophobic stressors including aliphatic alcohols, salts such as MgCl2, aromatics such as phenol, and hydrocarbons such as hexane and octene. We suggest that these stress parameters provide the (hitherto unidentified) modes-of-action for some extant antifungal products. The findings are discussed in relation to the development of a new generation of antifungals.

AB - Growth and metabolism of fungi can be curtailed by chaotropic solutes and hydrophobic substances, both of which can weaken or inhibit non-covalent interactions within and between macromolecular systems. Here we explore the potential to utilize the fungistatic and fungicidal activities of such stressors as the basis for commercial formulations. A method was developed for the quantification of chaotropicity, which can be used for chemically diverse substances, in order elucidate roles of chaotropicity and hydrophobicity in microbial ecology (both of which are sufficiently potent to limit the Earth’s microbial biosphere). A large number of naturally occurring substances act as chaotropic or hydrophobic stressors including aliphatic alcohols, salts such as MgCl2, aromatics such as phenol, and hydrocarbons such as hexane and octene. We suggest that these stress parameters provide the (hitherto unidentified) modes-of-action for some extant antifungal products. The findings are discussed in relation to the development of a new generation of antifungals.

M3 - Chapter

SN - 9783941261136

VL - VII

SP - 73

EP - 80

BT - Modern Fungicides and Antifungal Compounds VII: Proceedings of the 17th International Reinhardsbrunn Symposium April 21 -25, 2013, Friedrichroda, Germany

PB - Deutsche Phytomedizinische Gesellschaft

CY - Braunschweig

ER -

Cray JA, Bhaganna P, Singhal RS, Patil SV, Saha D, Chakraborty D et al. Chaotropic and hydrophobic stress mechanisms of antifungal substances. In Modern Fungicides and Antifungal Compounds VII: Proceedings of the 17th International Reinhardsbrunn Symposium April 21 -25, 2013, Friedrichroda, Germany. Vol. VII. Braunschweig: Deutsche Phytomedizinische Gesellschaft. 2014. p. 73-80