Abstract
The immune system protects the host against noxious insults, to maintain homeostasis and restore functionality. The retina is known as an immune privileged tissue due to its unique anatomic and physiologic properties. The retina has its own defence system including resident immune cells and the complement system. Retinal degenerative diseases are a major cause of blindness worldwide; the aetiology of each differs and inflammation plays a pivotal role in the development of these diseases. For example, inherited retinal degenerations are caused by specific gene mutations, an inflammatory response is secondary to photoreceptor death and may further participate in disease progression. Dysregulation or malfunction of the parainflammatory response contributes to age-related macular degeneration. Diabetic retinopathy is a major microvascular complication of long-term diabetes, which has a significant impact on the immune system. Glaucoma is a heterogeneous disorder related to retinal ganglion cell death from increased intraocular pressure. Neurodegenerative insults and glial activation initiate an immune response to restore tissue homeostasis and facilitate tissue repair and remodelling. This chapter discusses the basic principles of the immune response to common retinal insults in pathophysiological conditions and the contribution of such responses to retinal degeneration.
| Original language | English |
|---|---|
| Title of host publication | Royal Society of Chemistry |
| Editors | Thomas Cotter, Enrique J. de la Rosa |
| Publisher | Royal Society of Chemistry |
| Pages | 31-47 |
| Number of pages | 17 |
| Volume | 2019-January |
| Edition | 66 |
| DOIs | |
| Publication status | Published - 01 Jan 2019 |
Publication series
| Name | RSC Drug Discovery Series |
|---|---|
| ISSN (Print) | 2041-3203 |
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CHAPTER 2 : Immune response of the retina. / Chen, Mei; Xu, Heping.
Royal Society of Chemistry. ed. / Thomas Cotter; Enrique J. de la Rosa. Vol. 2019-January 66. ed. Royal Society of Chemistry, 2019. p. 31-47 (RSC Drug Discovery Series).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)
TY - CHAP
T1 - CHAPTER 2 : Immune response of the retina
AU - Chen, Mei
AU - Xu, Heping
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The immune system protects the host against noxious insults, to maintain homeostasis and restore functionality. The retina is known as an immune privileged tissue due to its unique anatomic and physiologic properties. The retina has its own defence system including resident immune cells and the complement system. Retinal degenerative diseases are a major cause of blindness worldwide; the aetiology of each differs and inflammation plays a pivotal role in the development of these diseases. For example, inherited retinal degenerations are caused by specific gene mutations, an inflammatory response is secondary to photoreceptor death and may further participate in disease progression. Dysregulation or malfunction of the parainflammatory response contributes to age-related macular degeneration. Diabetic retinopathy is a major microvascular complication of long-term diabetes, which has a significant impact on the immune system. Glaucoma is a heterogeneous disorder related to retinal ganglion cell death from increased intraocular pressure. Neurodegenerative insults and glial activation initiate an immune response to restore tissue homeostasis and facilitate tissue repair and remodelling. This chapter discusses the basic principles of the immune response to common retinal insults in pathophysiological conditions and the contribution of such responses to retinal degeneration.
AB - The immune system protects the host against noxious insults, to maintain homeostasis and restore functionality. The retina is known as an immune privileged tissue due to its unique anatomic and physiologic properties. The retina has its own defence system including resident immune cells and the complement system. Retinal degenerative diseases are a major cause of blindness worldwide; the aetiology of each differs and inflammation plays a pivotal role in the development of these diseases. For example, inherited retinal degenerations are caused by specific gene mutations, an inflammatory response is secondary to photoreceptor death and may further participate in disease progression. Dysregulation or malfunction of the parainflammatory response contributes to age-related macular degeneration. Diabetic retinopathy is a major microvascular complication of long-term diabetes, which has a significant impact on the immune system. Glaucoma is a heterogeneous disorder related to retinal ganglion cell death from increased intraocular pressure. Neurodegenerative insults and glial activation initiate an immune response to restore tissue homeostasis and facilitate tissue repair and remodelling. This chapter discusses the basic principles of the immune response to common retinal insults in pathophysiological conditions and the contribution of such responses to retinal degeneration.
UR - http://www.scopus.com/inward/record.url?scp=85056564740&partnerID=8YFLogxK
U2 - 10.1039/9781788013666-00031
DO - 10.1039/9781788013666-00031
M3 - Chapter (peer-reviewed)
AN - SCOPUS:85056564740
VL - 2019-January
T3 - RSC Drug Discovery Series
SP - 31
EP - 47
BT - Royal Society of Chemistry
A2 - Cotter, Thomas
A2 - de la Rosa, Enrique J.
PB - Royal Society of Chemistry
ER -