Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica

Candy Chuah, Malcolm K Jones, Donald P McManus, Sujeevi K Nawaratna, Melissa L Burke, Helen C Owen, Grant A Ramm, Geoffrey N Gobert

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

For hepatic schistosomiasis the egg-induced granulomatous response and the development of extensive fibrosis are the main pathologies. We used a Schistosoma japonicum-infected mouse model to characterise the multi-cellular pathways associated with the recovery from hepatic fibrosis following clearance of the infection with the anti-schistosomal drug, praziquantel. In the recovering liver splenomegaly, granuloma density and liver fibrosis were all reduced. Inflammatory cell infiltration into the liver was evident, and the numbers of neutrophils, eosinophils and macrophages were significantly decreased. Transcriptomic analysis revealed the up-regulation of fatty acid metabolism genes and the identification of Peroxisome proliferator activated receptor alpha as the upstream regulator of liver recovery. The aryl hydrocarbon receptor signalling pathway which regulates xenobiotic metabolism was also differentially up-regulated. These findings provide a better understanding of the mechanisms associated with the regression of hepatic schistosomiasis.

Original languageEnglish
Pages (from-to)239-52
Number of pages14
JournalInternational Journal for Parasitology
Volume46
Issue number4
Early online date23 Jan 2016
DOIs
Publication statusPublished - Apr 2016

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