Characteristics of a cetacean morbillivirus isolated from a porpoise (Phocoena phocoena)

M J Welsh, C Lyons, A Trudgett, B K Rima, S J McCullough, C Orvell

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12 Citations (Scopus)

Abstract

A virus isolated from a porpoise during the 1988 seal epizootic was shown to be a morbillivirus. In order to determine the relationship of the virus to phocine distemper virus (PDV) a battery of monoclonal antibodies raised against canine distemper virus (CDV), PDV or the porpoise isolate were assessed for their ability to bind to CDV, PDV or porpoise virus epitopes in indirect immunofluorescence assays and ELISAs. The porpoise isolate contained several unique epitopes and several epitopes present on CDV and PDV were absent on the porpoise isolate. The data presented in this study indicate that the porpoise virus is an antigenically distinct morbillivirus and as such has been tentatively named as delphinoid distemper virus (DDV).
Original languageEnglish
Pages (from-to)305-11
Number of pages7
JournalArchives of Virology
Volume125
Issue number1-4
Publication statusPublished - 1992

Keywords

  • Animals
  • Antibodies, Monoclonal
  • Antigens, Viral
  • Distemper Virus, Canine
  • Dolphins
  • Enzyme-Linked Immunosorbent Assay
  • Fluorescent Antibody Technique
  • Hybridomas
  • Mice
  • Mice, Inbred BALB C
  • Paramyxoviridae
  • Vero Cells
  • Viral Proteins

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