Abstract
In addition to hematopoietic progenitors, human bone marrow contains mature T/NK lymphocytes. Valpha24Vbeta11 NKT-cells, a subset of NK receptor+ (NKR+) T-cells in humans, are rare in bone marrow, suggesting the presence of other NKR+ T-cells which may contribute to tumor surveillance. NKR+/- T-cells were examined in blood (PB), and bone marrow from donors (DM) and patients with active hematopoietic malignancy (PM), or in remission (PR). T-cells in PR & PM were enriched for CD56+ and CD57+ subsets, compared to DM. All marrow NKR+/- T-cell subsets were more activated than PB. PM and, surprisingly, PR marrow contained more activated cells than DM. CD8+ cells were significantly increased in all patient marrows and there was evidence of the formation of an effector/memory pool in malignant marrow. These data suggest that NKR+ T-cell enrichment in human bone marrow that has been exposed to neoplastic transformation is compatible with a role in localized tumor surveillance/eradication.
Original language | English |
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Pages (from-to) | 42-51 |
Number of pages | 10 |
Journal | Clinical immunology (Orlando, Fla.) |
Volume | 114 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2005 |
Keywords
- Biological Markers
- Bone Marrow Cells
- Flow Cytometry
- Hematologic Neoplasms
- Humans
- Immunologic Memory
- Immunologic Surveillance
- Killer Cells, Natural
- Lymphocyte Activation
- T-Lymphocyte Subsets