Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes

Emma H. Allott*, Kellie Dean, Tracy Robson, Claire Meaney

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Our understanding of cancer initiation, progression, and treatment is continually progressing through dedicated research achieved through laboratory investigation, clinical trials, and patient engagement. The importance and complexity of the microenvironment and its role in tumor development and behavior is pivotal to the understanding of tumor growth and the best course of treatment. The 57th Irish Association for Cancer Research (IACR) Annual Conference collected key researchers, clinicians, and patient advocates together to highlight and discuss the recognized importance of the microenvironment and treatment advances in cancer. In this article, we describe the key components of the microenvironment that influence tumor development and treatment, including the microbiome, metabolism, and immune response and the progress of preclinical models to reflect these complex environments. From a psycho-social oncology perspective, we highlight expert opinion and data on the process of shared decision-making in the context of emerging cancer treatments.
Original languageEnglish
Article number5752
JournalCancers
Volume13
Issue number22
DOIs
Publication statusPublished - 17 Nov 2021

Keywords

  • microenvironment
  • immune system
  • microbiome
  • preclinical models
  • organoids
  • genetically engineered mouse models

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