CHD4 loss alters chromatin accessibility giving rise to sensitivity to DNA damage repair compounds in acute myeloid leukaemia

Deirdra Venney; Graeme M. Greenfield; Lauren V. Cairns; Paul Strain; Áine E. McGill; Jonathan J. Morgan; Róisín M. McAvera; Fatemeh Mirzadeh; Yaser Atlasi; Adone Mohd-Sarip; Ken I. Mills

doi:10.1182/blood-2022-162764

CHD4 loss alters chromatin accessibility giving rise to sensitivity to DNA damage repair compounds in acute myeloid leukaemia

Deirdra Venney^*, Graeme M. Greenfield, Lauren V. Cairns, Paul Strain, Áine E. McGill, Jonathan J. Morgan, Róisín M. McAvera, Fatemeh Mirzadeh, Yaser Atlasi, Adone Mohd-Sarip, Ken I. Mills

^*Corresponding author for this work

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Meeting abstract › peer-review

Original language	English
Pages (from-to)	8702-8703
Journal	Blood
Volume	140
Issue number	Supplement 1
DOIs	https://doi.org/10.1182/blood-2022-162764
Publication status	Published - 15 Nov 2022
Event	64th American Society of Hematology Annual Meeting - New Orleans, United States Duration: 10 Dec 2022 → 13 Dec 2022

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10.1182/blood-2022-162764Licence: Unspecified

Characterisation of novel molecular subtypes and corresponding pre-clinical models in AML, with implications for treatment response.
Strain, P. (Author), Blayney, J. (Supervisor) & Mills, K. (Supervisor), Jul 2024
Student thesis: Doctoral Thesis › Doctor of Philosophy
Determining effective radiation / drug combinations for paediatric cancers
McGill, A. (Author), Prise, K. (Supervisor) & Mills, K. (Supervisor), Jul 2024
Student thesis: Doctoral Thesis › Doctor of Philosophy
Elucidating the role of CHD4 as a chromatin and epigenetic modifier in acute myeloid leukaemia
Venney, D. (Author), Mills, K. (Supervisor), Tielenius Kruythoff-Mohd Sarip, A. (Supervisor) & Atlasi, Y. (Supervisor), Jul 2023
Student thesis: Doctoral Thesis › Doctor of Philosophy

Cite this

Venney, D., Greenfield, G. M., Cairns, L. V., Strain, P., McGill, Á. E., Morgan, J. J., McAvera, R. M., Mirzadeh, F., Atlasi, Y., Mohd-Sarip, A., & Mills, K. I. (2022). CHD4 loss alters chromatin accessibility giving rise to sensitivity to DNA damage repair compounds in acute myeloid leukaemia. Blood, 140(Supplement 1), 8702-8703. https://doi.org/10.1182/blood-2022-162764

@article{64e4d9cede144eb9935659f7715aff15,

title = "CHD4 loss alters chromatin accessibility giving rise to sensitivity to DNA damage repair compounds in acute myeloid leukaemia",

author = "Deirdra Venney and Greenfield, {Graeme M.} and Cairns, {Lauren V.} and Paul Strain and McGill, {{\'A}ine E.} and Morgan, {Jonathan J.} and McAvera, {R{\'o}is{\'i}n M.} and Fatemeh Mirzadeh and Yaser Atlasi and Adone Mohd-Sarip and Mills, {Ken I.}",

year = "2022",

month = nov,

day = "15",

doi = "10.1182/blood-2022-162764",

language = "English",

volume = "140",

pages = "8702--8703",

journal = "Blood",

issn = "1528-0020",

publisher = "AMER SOC HEMATOLOGY",

number = "Supplement 1",

note = "64th American Society of Hematology Annual Meeting ; Conference date: 10-12-2022 Through 13-12-2022",

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TY - JOUR

T1 - CHD4 loss alters chromatin accessibility giving rise to sensitivity to DNA damage repair compounds in acute myeloid leukaemia

AU - Venney, Deirdra

AU - Greenfield, Graeme M.

AU - Cairns, Lauren V.

AU - Strain, Paul

AU - McGill, Áine E.

AU - Morgan, Jonathan J.

AU - McAvera, Róisín M.

AU - Mirzadeh, Fatemeh

AU - Atlasi, Yaser

AU - Mohd-Sarip, Adone

AU - Mills, Ken I.

PY - 2022/11/15

Y1 - 2022/11/15

U2 - 10.1182/blood-2022-162764

DO - 10.1182/blood-2022-162764

M3 - Meeting abstract

SN - 1528-0020

VL - 140

SP - 8702

EP - 8703

JO - Blood

JF - Blood

IS - Supplement 1

T2 - 64th American Society of Hematology Annual Meeting

Y2 - 10 December 2022 through 13 December 2022

ER -

CHD4 loss alters chromatin accessibility giving rise to sensitivity to DNA damage repair compounds in acute myeloid leukaemia

Access to Document

Student theses

Characterisation of novel molecular subtypes and corresponding pre-clinical models in AML, with implications for treatment response.

Determining effective radiation / drug combinations for paediatric cancers

Elucidating the role of CHD4 as a chromatin and epigenetic modifier in acute myeloid leukaemia

Cite this