Abstract
Given the relative inaccessibility of the target tissue - the Central Nervous System (CNS) - to experimental exploration, a wide range of in vivo experimental models are employed to study multiple sclerosis (MS), each of which affords particular suitability to studying different aspects of the disease. Individual models exhibit similarities to different types of histopathological lesions (type I-IV) described in MS. Most commonly, rodent models are used with mice being the most frequent choice, due in part to the range of reagents and genetically modified (GM) lines available as well as the reduced cost and breeding time of this species compared to larger mammals. While this chapter will primarily focus on the range of experimental autoimmune encephalomyelitis (EAE) models, it is important to summarise other approaches taken to model CNS demyelination. Aside of EAE, which will be discussed in detail later, three other main categories of models are frequently used: toxin-induced demyelination, viral-induced demyelination and genetic manipulation resulting in de-/dysmyelination. These models have been reviewed in depth elsewhere.
| Original language | English |
|---|---|
| Title of host publication | Multiple Sclerosis Immunology |
| Subtitle of host publication | A Foundation for Current and Future Treatments |
| Publisher | Springer New York |
| Pages | 269-293 |
| Number of pages | 25 |
| ISBN (Electronic) | 9781461479536 |
| ISBN (Print) | 1461479525, 9781461479529 |
| DOIs | |
| Publication status | Published - 01 Nov 2013 |
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Checkpoints in the development of pathogenic and regulatory T cells in experimental autoimmune encephalomyelitis-A basis for current and future interventions in MS. / Fitzgerald, Denise C.; Anderton, Stephen M.
Multiple Sclerosis Immunology: A Foundation for Current and Future Treatments. Springer New York, 2013. p. 269-293.Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - Checkpoints in the development of pathogenic and regulatory T cells in experimental autoimmune encephalomyelitis-A basis for current and future interventions in MS
AU - Fitzgerald, Denise C.
AU - Anderton, Stephen M.
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Given the relative inaccessibility of the target tissue - the Central Nervous System (CNS) - to experimental exploration, a wide range of in vivo experimental models are employed to study multiple sclerosis (MS), each of which affords particular suitability to studying different aspects of the disease. Individual models exhibit similarities to different types of histopathological lesions (type I-IV) described in MS. Most commonly, rodent models are used with mice being the most frequent choice, due in part to the range of reagents and genetically modified (GM) lines available as well as the reduced cost and breeding time of this species compared to larger mammals. While this chapter will primarily focus on the range of experimental autoimmune encephalomyelitis (EAE) models, it is important to summarise other approaches taken to model CNS demyelination. Aside of EAE, which will be discussed in detail later, three other main categories of models are frequently used: toxin-induced demyelination, viral-induced demyelination and genetic manipulation resulting in de-/dysmyelination. These models have been reviewed in depth elsewhere.
AB - Given the relative inaccessibility of the target tissue - the Central Nervous System (CNS) - to experimental exploration, a wide range of in vivo experimental models are employed to study multiple sclerosis (MS), each of which affords particular suitability to studying different aspects of the disease. Individual models exhibit similarities to different types of histopathological lesions (type I-IV) described in MS. Most commonly, rodent models are used with mice being the most frequent choice, due in part to the range of reagents and genetically modified (GM) lines available as well as the reduced cost and breeding time of this species compared to larger mammals. While this chapter will primarily focus on the range of experimental autoimmune encephalomyelitis (EAE) models, it is important to summarise other approaches taken to model CNS demyelination. Aside of EAE, which will be discussed in detail later, three other main categories of models are frequently used: toxin-induced demyelination, viral-induced demyelination and genetic manipulation resulting in de-/dysmyelination. These models have been reviewed in depth elsewhere.
UR - http://www.scopus.com/inward/record.url?scp=84929556272&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-7953-6_13
DO - 10.1007/978-1-4614-7953-6_13
M3 - Chapter
AN - SCOPUS:84929556272
SN - 1461479525
SN - 9781461479529
SP - 269
EP - 293
BT - Multiple Sclerosis Immunology
PB - Springer New York
ER -