Chemoenzymatic Synthesis of Carbasugars (+)-Pericosines A-C from Diverse Aromatic cis-Dihydrodiol Precursors

Derek Boyd, Narain Sharma, Carmen Acaru, John Malone, Colin O'Dowd, Christopher Allen, Paul Stevenson

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

cis-Dihydrocatechols, derived from biological cis-dihydroxylation of methyl benzoate, iodobenzene and benzonitrile, using the microorganism Pseudomonas putida UV4, were converted into pericosines A, C, and B, respectively. This approach constitutes the shortest syntheses, to date, of these important natural products with densely packed functionalities.
Original languageEnglish
Pages (from-to)2206-2209
Number of pages4
JournalOrganic Letters
Volume12
Issue number10
Early online date22 Apr 2010
DOIs
Publication statusPublished - 21 May 2010

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry

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