ChIPping away at gene regulation

Charles E Massie, Ian G Mills

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

The coordinated regulation of gene expression in higher eukaryotes is complex and poorly understood. Recent technological advances have allowed the first insights into these networks on a genome-wide scale. These investigations have identified transcription factor target sites in the genome and successfully predicted cooperative interactions with other factors. However, a detailed understanding of the processes that coordinate gene expression remains elusive. Here, we highlight the advances that have been made using current methods, and the need for new technologies to address the gaps in our knowledge and to map these complex pathways further.

Original languageEnglish
Pages (from-to)337-43
Number of pages7
JournalEMBO Reports
Volume9
Issue number4
DOIs
Publication statusPublished - Apr 2008

Keywords

  • Binding Sites
  • Chromatin Immunoprecipitation
  • Gene Expression Regulation
  • Transcription Factors

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