Chlamydia pneumoniae antibodies are associated with an atherogenic lipid profile

L. J. Murray*, D. P.J. O'Reilly, G. M.L. Ong, C. O'Neill, A. E. Evans, K. B. Bamford

*Corresponding author for this work

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objective - To determine, within a representative population group of men and women, whether alteration of the lipid profile might underlie the reported association between Chlamydia pneumoniae and ischaemic heart disease. Design and setting - Cross sectional survey in an area with a high incidence of ischaemic heart disease. Subjects - 400 randomly selected participants in the World Health Organisation MONICA project's third population survey in Northern Ireland. Main outcome measures - Stored sera were examined by microimmunofluorescence for IgG antibodies to C pneumoniae at a dilution of 1 in 64. Mean total and high density lipoprotein (HDL) cholesterol were compared between seropositive and seronegative individuals with adjustment for age, measures of socioeconomic status, smoking habit, alcohol consumption, body mass index, and the season during which blood had been taken. Results - In seropositive men, adjusted mean serum total cholesterol and HDL cholesterol were 0.5 mmol/1 (9.2%) higher and 0.11 mmol/1 (9.3%) lower, respectively, than in seronegative men. Differences in women did not achieve statistical significance, hut both total cholesterol and HDL cholesterol were higher (3.6% and 5.8%, respectively) in seropositive than in seronegative individuals. Conclusions - There is serological evidence that C pneumoniae infection is associated with an atherogenic lipid profile in men. Altered lipid levels may underlie the association between C pneumoniae and ischaemic heart disease.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalHeart
Volume81
Issue number3
DOIs
Publication statusPublished - 01 Jan 1999

Keywords

  • Cholesterol
  • Epidemiology
  • Ischaemic heart disease
  • Lipids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Chlamydia pneumoniae antibodies are associated with an atherogenic lipid profile'. Together they form a unique fingerprint.

  • Cite this