Chloroquine causes lysosomal dysfunction in neural retina and RPE: Implications for retinopathy

Gerald Mahon, Heather Anderson, Tom Gardiner, Suzanne McFarlane, Desmond Archer, Alan Stitt

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Chronic use of chloroquine has been shown to induce numerous pathophysiological defects in the retina. This drug has the ability to alter pH of intracellular compartments and lysosomal function of the retinal pigment epithelium (RPE) and retinal neurons may constitute the basis of chloroquine retinopathy. The aim of the current study was to investigate pathogenic alterations in retinal cells continuously exposed to chloroquine using appropriate in vivo and in vitro models.
Original languageEnglish
Pages (from-to)277-284
Number of pages8
JournalCurrent eye research
Volume28
Issue number4
Publication statusPublished - Apr 2004

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Fingerprint Dive into the research topics of 'Chloroquine causes lysosomal dysfunction in neural retina and RPE: Implications for retinopathy'. Together they form a unique fingerprint.

  • Cite this