Chronic use of chloroquine has been shown to induce numerous pathophysiological defects in the retina. This drug has the ability to alter pH of intracellular compartments and lysosomal function of the retinal pigment epithelium (RPE) and retinal neurons may constitute the basis of chloroquine retinopathy. The aim of the current study was to investigate pathogenic alterations in retinal cells continuously exposed to chloroquine using appropriate in vivo and in vitro models.
|Number of pages||8|
|Journal||Current eye research|
|Publication status||Published - Apr 2004|
ASJC Scopus subject areas
- Sensory Systems
Mahon, G., Anderson, H., Gardiner, T., McFarlane, S., Archer, D., & Stitt, A. (2004). Chloroquine causes lysosomal dysfunction in neural retina and RPE: Implications for retinopathy. Current eye research, 28(4), 277-284.