Choroidal vascularity in chronic central serous chorioretinopathy and its association with risk single-nucleotide polymorphisms

Rebecca A Kaye; Tunde Peto; Ruth Hogg; Helen Griffiths; Sobha Sivaprasad; Andrew J Lotery; The VICI Trial

doi:10.1097/IAE.0000000000004024

Choroidal vascularity in chronic central serous chorioretinopathy and its association with risk single-nucleotide polymorphisms

Rebecca A Kaye, Tunde Peto, Ruth Hogg, Helen Griffiths, Sobha Sivaprasad, Andrew J Lotery, The VICI Trial

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Purpose:
To analyse the choroidal parameters of patients with chronic central serous chorioretinopathy (cCSC), and the association with CSC susceptibility genes.

Methods:
The choroidal vascular index (CVI) was obtained by binarizing spectral domain optical coherence tomography (OCT) enhanced depth images of cCSC patients and healthy age-matched controls. cCSC patients were genotyped for three CSC susceptibility SNPs: rs4844392 (mir-29b-2/CD46), rs1329428 (CFH) and rs2379120 (upstream GATA5).

Results:
103 eyes with cCSC and 53 control eyes were included. There was a significant increase in the sub-foveal choroidal area in in both the affected (2.4 ± 0.6mm2) and fellow (2.2 ± 0.6mm2) eyes of patients with cCSC compared to controls (1.8 ± 0.5mm2, (p<0.0001 and p<0.0001). The CVI was reduced in cCSC patients 63.5 ± 3.1% compared to controls 65.4 ± 2.3% (p<0.001) and also in the affected compared to the fellow eyes 64.6 ± 2.9% (p<0.01). There was a significant association between CVI in the cCSC group and presence of the risk SNP rs2379120 at GATA5 (p<0.01).

Conclusion:
The relative reduction of CVI in cCSC patients may suggest a persistence of vessel hyper-permeability over dilation in chronic disease. GATA5 is associated with CVI in cCSC patients and therefore, may have a role in choroidal vascularity.

Original language	English
Pages (from-to)	837-843
Number of pages	7
Journal	Retina
Volume	44
Issue number	5
Early online date	12 Dec 2023
DOIs	https://doi.org/10.1097/IAE.0000000000004024
Publication status	Published - May 2024

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10.1097/IAE.0000000000004024Licence: CC BY

Choroidal vascularity in chronic central serous chorioretinopathy and its association with risk single-nucleotide polymorphisms
Copyright 2024 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 576 KBLicence: CC BY

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title = "Choroidal vascularity in chronic central serous chorioretinopathy and its association with risk single-nucleotide polymorphisms",

abstract = "Purpose: To analyse the choroidal parameters of patients with chronic central serous chorioretinopathy (cCSC), and the association with CSC susceptibility genes. Methods: The choroidal vascular index (CVI) was obtained by binarizing spectral domain optical coherence tomography (OCT) enhanced depth images of cCSC patients and healthy age-matched controls. cCSC patients were genotyped for three CSC susceptibility SNPs: rs4844392 (mir-29b-2/CD46), rs1329428 (CFH) and rs2379120 (upstream GATA5). Results: 103 eyes with cCSC and 53 control eyes were included. There was a significant increase in the sub-foveal choroidal area in in both the affected (2.4 ± 0.6mm2) and fellow (2.2 ± 0.6mm2) eyes of patients with cCSC compared to controls (1.8 ± 0.5mm2, (p<0.0001 and p<0.0001). The CVI was reduced in cCSC patients 63.5 ± 3.1\% compared to controls 65.4 ± 2.3\% (p<0.001) and also in the affected compared to the fellow eyes 64.6 ± 2.9\% (p<0.01). There was a significant association between CVI in the cCSC group and presence of the risk SNP rs2379120 at GATA5 (p<0.01). Conclusion: The relative reduction of CVI in cCSC patients may suggest a persistence of vessel hyper-permeability over dilation in chronic disease. GATA5 is associated with CVI in cCSC patients and therefore, may have a role in choroidal vascularity.",

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doi = "10.1097/IAE.0000000000004024",

language = "English",

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T1 - Choroidal vascularity in chronic central serous chorioretinopathy and its association with risk single-nucleotide polymorphisms

AU - Kaye, Rebecca A

AU - Peto, Tunde

AU - Hogg, Ruth

AU - Griffiths, Helen

AU - Sivaprasad, Sobha

AU - Lotery, Andrew J

AU - The VICI Trial

PY - 2024/5

Y1 - 2024/5

N2 - Purpose: To analyse the choroidal parameters of patients with chronic central serous chorioretinopathy (cCSC), and the association with CSC susceptibility genes. Methods: The choroidal vascular index (CVI) was obtained by binarizing spectral domain optical coherence tomography (OCT) enhanced depth images of cCSC patients and healthy age-matched controls. cCSC patients were genotyped for three CSC susceptibility SNPs: rs4844392 (mir-29b-2/CD46), rs1329428 (CFH) and rs2379120 (upstream GATA5). Results: 103 eyes with cCSC and 53 control eyes were included. There was a significant increase in the sub-foveal choroidal area in in both the affected (2.4 ± 0.6mm2) and fellow (2.2 ± 0.6mm2) eyes of patients with cCSC compared to controls (1.8 ± 0.5mm2, (p<0.0001 and p<0.0001). The CVI was reduced in cCSC patients 63.5 ± 3.1% compared to controls 65.4 ± 2.3% (p<0.001) and also in the affected compared to the fellow eyes 64.6 ± 2.9% (p<0.01). There was a significant association between CVI in the cCSC group and presence of the risk SNP rs2379120 at GATA5 (p<0.01). Conclusion: The relative reduction of CVI in cCSC patients may suggest a persistence of vessel hyper-permeability over dilation in chronic disease. GATA5 is associated with CVI in cCSC patients and therefore, may have a role in choroidal vascularity.

AB - Purpose: To analyse the choroidal parameters of patients with chronic central serous chorioretinopathy (cCSC), and the association with CSC susceptibility genes. Methods: The choroidal vascular index (CVI) was obtained by binarizing spectral domain optical coherence tomography (OCT) enhanced depth images of cCSC patients and healthy age-matched controls. cCSC patients were genotyped for three CSC susceptibility SNPs: rs4844392 (mir-29b-2/CD46), rs1329428 (CFH) and rs2379120 (upstream GATA5). Results: 103 eyes with cCSC and 53 control eyes were included. There was a significant increase in the sub-foveal choroidal area in in both the affected (2.4 ± 0.6mm2) and fellow (2.2 ± 0.6mm2) eyes of patients with cCSC compared to controls (1.8 ± 0.5mm2, (p<0.0001 and p<0.0001). The CVI was reduced in cCSC patients 63.5 ± 3.1% compared to controls 65.4 ± 2.3% (p<0.001) and also in the affected compared to the fellow eyes 64.6 ± 2.9% (p<0.01). There was a significant association between CVI in the cCSC group and presence of the risk SNP rs2379120 at GATA5 (p<0.01). Conclusion: The relative reduction of CVI in cCSC patients may suggest a persistence of vessel hyper-permeability over dilation in chronic disease. GATA5 is associated with CVI in cCSC patients and therefore, may have a role in choroidal vascularity.

U2 - 10.1097/IAE.0000000000004024

DO - 10.1097/IAE.0000000000004024

M3 - Article

C2 - 38109714

SN - 0275-004X

VL - 44

SP - 837

EP - 843

JO - Retina

JF - Retina

IS - 5

ER -

Choroidal vascularity in chronic central serous chorioretinopathy and its association with risk single-nucleotide polymorphisms

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