Chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts

Nicole Liew, Maria J Mazon Moya, Claudia J Wierzbicki, Michael Hollinshead, Michael J Dillon, Christopher R Thornton, Amy Ellison, Jo Cable, Matthew C Fisher, Serge Mostowy

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10 Citations (Scopus)
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Abstract

Aquatic chytrid fungi threaten amphibian biodiversity worldwide owing to their ability to rapidly expand their geographical distributions and to infect a wide range of hosts. Combating this risk requires an understanding of chytrid host range to identify potential reservoirs of infection and to safeguard uninfected regions through enhanced biosecurity. Here we extend our knowledge on the host range of the chytrid Batrachochytrium dendrobatidis by demonstrating infection of a non-amphibian vertebrate host, the zebrafish. We observe dose-dependent mortality and show that chytrid can infect and proliferate on zebrafish tissue. We also show that infection phenotypes (fin erosion, cell apoptosis and muscle degeneration) are direct symptoms of infection. Successful infection is dependent on disrupting the zebrafish microbiome, highlighting that, as is widely found in amphibians, commensal bacteria confer protection against this pathogen. Collectively, our findings greatly expand the limited tool kit available to study pathogenesis and host response to chytrid infection.

Original languageEnglish
Pages (from-to)15048
JournalNature Communications
Volume8
DOIs
Publication statusPublished - 20 Apr 2017
Externally publishedYes

Keywords

  • Amphibians/microbiology
  • Animal Fins/microbiology
  • Animals
  • Chytridiomycota/physiology
  • Fish Diseases/microbiology
  • Host-Pathogen Interactions
  • Microbial Interactions
  • Microbiota/physiology
  • Zebrafish/microbiology

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  • Cite this

    Liew, N., Mazon Moya, M. J., Wierzbicki, C. J., Hollinshead, M., Dillon, M. J., Thornton, C. R., Ellison, A., Cable, J., Fisher, M. C., & Mostowy, S. (2017). Chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts. Nature Communications, 8, 15048. https://doi.org/10.1038/ncomms15048