Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort

A. Fanidi; D. C. Muller; O. Midttun; P. M. Ueland; S. E. Vollset; C. Relton; P. Vineis; E. Weiderpass; G. Skeie; M. Brustad; D. Palli; R. Tumino; S. Grioni; C. Sacerdote; H. B. Bueno-de-Mesquita; P. H. Peeters; M. C. Boutron-Ruault; M. Kvaskoff; C. Cadeau; J. M. Huerta; M. J. Sanchez; A. Agudo; C. Lasheras; J. R. Quiros; S. Chamosa; E. Riboli; R. C. Travis; H. Ward; K. T. Khaw; A. Trichopoulou; P. Lagiou; E. M. Papatesta; H. Boeing; T. Kuehn; V. Katzke; A. Steffen; A. Johansson; M. Johansson

doi:10.1038/srep36017

Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort

A. Fanidi, D. C. Muller, O. Midttun, P. M. Ueland, S. E. Vollset, C. Relton, P. Vineis, E. Weiderpass, G. Skeie, M. Brustad, D. Palli, R. Tumino, S. Grioni, C. Sacerdote, H. B. Bueno-de-Mesquita, P. H. Peeters, M. C. Boutron-Ruault, M. Kvaskoff, C. Cadeau, J. M. HuertaM. J. Sanchez, A. Agudo, C. Lasheras, J. R. Quiros, S. Chamosa, E. Riboli, R. C. Travis, H. Ward, K. T. Khaw, A. Trichopoulou, P. Lagiou, E. M. Papatesta, H. Boeing, T. Kuehn, V. Katzke, A. Steffen, A. Johansson, M. Johansson

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

61 Downloads (Pure)

Abstract

Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and
progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer
are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited
385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating
25(OH)D3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophagus
cancer risk and post-diagnosis all-cause mortality. After controlling for risk factors, a doubling of 25(OH)
D3 was associated with 30% lower odds of HNC (OR 0.70, 95% confidence interval [95% CI] 0.56–0.88,
Ptrend=0.001). Subsequent analyses by anatomical sub-site indicated clear inverse associations with
risk of larynx and hypopharynx cancer combined (OR 0.55, 95CI% 0.39–0.78) and oral cavity cancer (OR
0.60, 95CI% 0.42–0.87). Low 25(OH)D3 concentrations were also associated with higher risk of death
from any cause among HNC cases. No clear association was seen with risk or survival for oesophageal
cancer. Study participants with elevated circulating concentrations of 25(OH)D3 had decreased risk of
HNC, as well as improved survival following diagnosis.

Original language	Undefined/Unknown
Pages (from-to)	36017
Number of pages	11
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep36017
Publication status	Published - 04 Nov 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/srep36017Licence: CC BY

Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort
© 2016 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.13 MBLicence: CC BY

Cite this

Fanidi, A., Muller, D. C., Midttun, O., Ueland, P. M., Vollset, S. E., Relton, C., Vineis, P., Weiderpass, E., Skeie, G., Brustad, M., Palli, D., Tumino, R., Grioni, S., Sacerdote, C., Bueno-de-Mesquita, H. B., Peeters, P. H., Boutron-Ruault, M. C., Kvaskoff, M., Cadeau, C., ... Johansson, M. (2016). Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort. Scientific Reports, 6, 36017. https://doi.org/10.1038/srep36017

@article{86cbc97cfc0c4b29b6533d3565412e53,

title = "Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort",

abstract = "Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis andprogression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancerare limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating25(OH)D3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophaguscancer risk and post-diagnosis all-cause mortality. After controlling for risk factors, a doubling of 25(OH)D3 was associated with 30% lower odds of HNC (OR 0.70, 95% confidence interval [95% CI] 0.56–0.88,Ptrend=0.001). Subsequent analyses by anatomical sub-site indicated clear inverse associations withrisk of larynx and hypopharynx cancer combined (OR 0.55, 95CI% 0.39–0.78) and oral cavity cancer (OR0.60, 95CI% 0.42–0.87). Low 25(OH)D3 concentrations were also associated with higher risk of deathfrom any cause among HNC cases. No clear association was seen with risk or survival for oesophagealcancer. Study participants with elevated circulating concentrations of 25(OH)D3 had decreased risk ofHNC, as well as improved survival following diagnosis.",

author = "A. Fanidi and Muller, {D. C.} and O. Midttun and Ueland, {P. M.} and Vollset, {S. E.} and C. Relton and P. Vineis and E. Weiderpass and G. Skeie and M. Brustad and D. Palli and R. Tumino and S. Grioni and C. Sacerdote and Bueno-de-Mesquita, {H. B.} and Peeters, {P. H.} and Boutron-Ruault, {M. C.} and M. Kvaskoff and C. Cadeau and Huerta, {J. M.} and Sanchez, {M. J.} and A. Agudo and C. Lasheras and Quiros, {J. R.} and S. Chamosa and E. Riboli and Travis, {R. C.} and H. Ward and Khaw, {K. T.} and A. Trichopoulou and P. Lagiou and Papatesta, {E. M.} and H. Boeing and T. Kuehn and V. Katzke and A. Steffen and A. Johansson and M. Johansson",

year = "2016",

month = nov,

day = "4",

doi = "10.1038/srep36017",

language = "Undefined/Unknown",

volume = "6",

pages = "36017",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

Fanidi, A, Muller, DC, Midttun, O, Ueland, PM, Vollset, SE, Relton, C, Vineis, P, Weiderpass, E, Skeie, G, Brustad, M, Palli, D, Tumino, R, Grioni, S, Sacerdote, C, Bueno-de-Mesquita, HB, Peeters, PH, Boutron-Ruault, MC, Kvaskoff, M, Cadeau, C, Huerta, JM, Sanchez, MJ, Agudo, A, Lasheras, C, Quiros, JR, Chamosa, S, Riboli, E, Travis, RC, Ward, H, Khaw, KT, Trichopoulou, A, Lagiou, P, Papatesta, EM, Boeing, H, Kuehn, T, Katzke, V, Steffen, A, Johansson, A & Johansson, M 2016, 'Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort', Scientific Reports, vol. 6, pp. 36017. https://doi.org/10.1038/srep36017

TY - JOUR

T1 - Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort

AU - Fanidi, A.

AU - Muller, D. C.

AU - Midttun, O.

AU - Ueland, P. M.

AU - Vollset, S. E.

AU - Relton, C.

AU - Vineis, P.

AU - Weiderpass, E.

AU - Skeie, G.

AU - Brustad, M.

AU - Palli, D.

AU - Tumino, R.

AU - Grioni, S.

AU - Sacerdote, C.

AU - Bueno-de-Mesquita, H. B.

AU - Peeters, P. H.

AU - Boutron-Ruault, M. C.

AU - Kvaskoff, M.

AU - Cadeau, C.

AU - Huerta, J. M.

AU - Sanchez, M. J.

AU - Agudo, A.

AU - Lasheras, C.

AU - Quiros, J. R.

AU - Chamosa, S.

AU - Riboli, E.

AU - Travis, R. C.

AU - Ward, H.

AU - Khaw, K. T.

AU - Trichopoulou, A.

AU - Lagiou, P.

AU - Papatesta, E. M.

AU - Boeing, H.

AU - Kuehn, T.

AU - Katzke, V.

AU - Steffen, A.

AU - Johansson, A.

AU - Johansson, M.

PY - 2016/11/4

Y1 - 2016/11/4

N2 - Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis andprogression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancerare limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating25(OH)D3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophaguscancer risk and post-diagnosis all-cause mortality. After controlling for risk factors, a doubling of 25(OH)D3 was associated with 30% lower odds of HNC (OR 0.70, 95% confidence interval [95% CI] 0.56–0.88,Ptrend=0.001). Subsequent analyses by anatomical sub-site indicated clear inverse associations withrisk of larynx and hypopharynx cancer combined (OR 0.55, 95CI% 0.39–0.78) and oral cavity cancer (OR0.60, 95CI% 0.42–0.87). Low 25(OH)D3 concentrations were also associated with higher risk of deathfrom any cause among HNC cases. No clear association was seen with risk or survival for oesophagealcancer. Study participants with elevated circulating concentrations of 25(OH)D3 had decreased risk ofHNC, as well as improved survival following diagnosis.

AB - Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis andprogression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancerare limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating25(OH)D3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophaguscancer risk and post-diagnosis all-cause mortality. After controlling for risk factors, a doubling of 25(OH)D3 was associated with 30% lower odds of HNC (OR 0.70, 95% confidence interval [95% CI] 0.56–0.88,Ptrend=0.001). Subsequent analyses by anatomical sub-site indicated clear inverse associations withrisk of larynx and hypopharynx cancer combined (OR 0.55, 95CI% 0.39–0.78) and oral cavity cancer (OR0.60, 95CI% 0.42–0.87). Low 25(OH)D3 concentrations were also associated with higher risk of deathfrom any cause among HNC cases. No clear association was seen with risk or survival for oesophagealcancer. Study participants with elevated circulating concentrations of 25(OH)D3 had decreased risk ofHNC, as well as improved survival following diagnosis.

U2 - 10.1038/srep36017

DO - 10.1038/srep36017

M3 - Article

SN - 2045-2322

VL - 6

SP - 36017

JO - Scientific Reports

JF - Scientific Reports

ER -