Citrus fruits intake and oral cancer risk: A systematic review and meta-analysis

Santa Cirmi, Michele Navarra, Jayne V Woodside, Marie M Cantwell

Research output: Contribution to journalReview article

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Abstract

OBJECTIVE: To quantify the relationship between Citrus intake and risk of cancer of the oral cavity and pharynx.

DESIGN: Systematic review and meta-analysis.

DATA SOURCES: Ovid MEDLINE, EMBASE, and Web of Science were searched until September 2017. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, Citrus oil, fruits, oral cancer, mouth cancer, mouth neoplasm.

STUDY SELECTION: The selection of studies and the systematic review were carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A pre-defined inclusion checklist resulted in the inclusion of articles which were (i) published in peer-reviewed scientific journals; (ii) English language; (iii) and included a measure of Citrus fruit intake and risk of oral and pharyngeal cancer. Studies were excluded if (i) preparations derived from other fruits were used, (ii) Citrus intake was combined with intake of other fruits; (iii) in vitro or animal models were used. We also excluded reviews, systematic reviews, meta-analyses, letters, personal opinions, conference abstracts and book chapters.

DATA EXTRACTION: Three reviewers independently performed the extraction of data from studies included.

RESULTS: Seventeen studies met our inclusion criteria and were included in the final review. Pooled analyses showed that those with the highest Citrus fruit intake compared to the lowest intake had a 50% reduction in risk of oral cavity and pharyngeal cancer (OR 0.50; 95% CI 0.43-0.59).

CONCLUSION: The studies included in this review and meta-analysis showed an inverse association between Citrus fruit intake and oral cancer.

Original languageEnglish
Pages (from-to)187-194
JournalPharmacological Research
Volume133
Early online date16 May 2018
DOIs
Publication statusPublished - Jul 2018

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Citrus
Mouth Neoplasms
Meta-Analysis
Pharyngeal Neoplasms
Mouth
Fruit
Citrus paradisi
Risk Reduction Behavior
Checklist
MEDLINE
Oils
Language
Animal Models

Cite this

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title = "Citrus fruits intake and oral cancer risk: A systematic review and meta-analysis",
abstract = "OBJECTIVE: To quantify the relationship between Citrus intake and risk of cancer of the oral cavity and pharynx.DESIGN: Systematic review and meta-analysis.DATA SOURCES: Ovid MEDLINE, EMBASE, and Web of Science were searched until September 2017. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, Citrus oil, fruits, oral cancer, mouth cancer, mouth neoplasm.STUDY SELECTION: The selection of studies and the systematic review were carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A pre-defined inclusion checklist resulted in the inclusion of articles which were (i) published in peer-reviewed scientific journals; (ii) English language; (iii) and included a measure of Citrus fruit intake and risk of oral and pharyngeal cancer. Studies were excluded if (i) preparations derived from other fruits were used, (ii) Citrus intake was combined with intake of other fruits; (iii) in vitro or animal models were used. We also excluded reviews, systematic reviews, meta-analyses, letters, personal opinions, conference abstracts and book chapters.DATA EXTRACTION: Three reviewers independently performed the extraction of data from studies included.RESULTS: Seventeen studies met our inclusion criteria and were included in the final review. Pooled analyses showed that those with the highest Citrus fruit intake compared to the lowest intake had a 50{\%} reduction in risk of oral cavity and pharyngeal cancer (OR 0.50; 95{\%} CI 0.43-0.59).CONCLUSION: The studies included in this review and meta-analysis showed an inverse association between Citrus fruit intake and oral cancer.",
author = "Santa Cirmi and Michele Navarra and Woodside, {Jayne V} and Cantwell, {Marie M}",
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year = "2018",
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Citrus fruits intake and oral cancer risk: A systematic review and meta-analysis. / Cirmi, Santa; Navarra, Michele; Woodside, Jayne V; Cantwell, Marie M.

In: Pharmacological Research, Vol. 133, 07.2018, p. 187-194.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Citrus fruits intake and oral cancer risk: A systematic review and meta-analysis

AU - Cirmi, Santa

AU - Navarra, Michele

AU - Woodside, Jayne V

AU - Cantwell, Marie M

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018/7

Y1 - 2018/7

N2 - OBJECTIVE: To quantify the relationship between Citrus intake and risk of cancer of the oral cavity and pharynx.DESIGN: Systematic review and meta-analysis.DATA SOURCES: Ovid MEDLINE, EMBASE, and Web of Science were searched until September 2017. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, Citrus oil, fruits, oral cancer, mouth cancer, mouth neoplasm.STUDY SELECTION: The selection of studies and the systematic review were carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A pre-defined inclusion checklist resulted in the inclusion of articles which were (i) published in peer-reviewed scientific journals; (ii) English language; (iii) and included a measure of Citrus fruit intake and risk of oral and pharyngeal cancer. Studies were excluded if (i) preparations derived from other fruits were used, (ii) Citrus intake was combined with intake of other fruits; (iii) in vitro or animal models were used. We also excluded reviews, systematic reviews, meta-analyses, letters, personal opinions, conference abstracts and book chapters.DATA EXTRACTION: Three reviewers independently performed the extraction of data from studies included.RESULTS: Seventeen studies met our inclusion criteria and were included in the final review. Pooled analyses showed that those with the highest Citrus fruit intake compared to the lowest intake had a 50% reduction in risk of oral cavity and pharyngeal cancer (OR 0.50; 95% CI 0.43-0.59).CONCLUSION: The studies included in this review and meta-analysis showed an inverse association between Citrus fruit intake and oral cancer.

AB - OBJECTIVE: To quantify the relationship between Citrus intake and risk of cancer of the oral cavity and pharynx.DESIGN: Systematic review and meta-analysis.DATA SOURCES: Ovid MEDLINE, EMBASE, and Web of Science were searched until September 2017. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, Citrus oil, fruits, oral cancer, mouth cancer, mouth neoplasm.STUDY SELECTION: The selection of studies and the systematic review were carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A pre-defined inclusion checklist resulted in the inclusion of articles which were (i) published in peer-reviewed scientific journals; (ii) English language; (iii) and included a measure of Citrus fruit intake and risk of oral and pharyngeal cancer. Studies were excluded if (i) preparations derived from other fruits were used, (ii) Citrus intake was combined with intake of other fruits; (iii) in vitro or animal models were used. We also excluded reviews, systematic reviews, meta-analyses, letters, personal opinions, conference abstracts and book chapters.DATA EXTRACTION: Three reviewers independently performed the extraction of data from studies included.RESULTS: Seventeen studies met our inclusion criteria and were included in the final review. Pooled analyses showed that those with the highest Citrus fruit intake compared to the lowest intake had a 50% reduction in risk of oral cavity and pharyngeal cancer (OR 0.50; 95% CI 0.43-0.59).CONCLUSION: The studies included in this review and meta-analysis showed an inverse association between Citrus fruit intake and oral cancer.

U2 - 10.1016/j.phrs.2018.05.008

DO - 10.1016/j.phrs.2018.05.008

M3 - Review article

C2 - 29753688

VL - 133

SP - 187

EP - 194

JO - Pharmacological Research

JF - Pharmacological Research

SN - 1043-6618

ER -