Clinical and technical factors associated with skin intrinsic fluorescence in subjects with type 1 diabetes from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study

Patricia A Cleary, Barbara H Braffett, Trevor Orchard, Timothy J Lyons, John Maynard, Catherine Cowie, Rose A Gubitosi-Klug, Jeff Way, Karen Anderson, Annette Barnie, Stephan Villavicencio, DCCT/EDIC Research Group

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

The Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications(EDIC) studies have established multiyear mean hemoglobin A1c (HbA1c) as predictive of microvascular complications in persons with type 1 diabetes. However, multiyear mean HbA1c is not always available in the clinical setting. Skin advanced glycation end products (AGEs) are thought to partially reflect effects of hyperglycemia over time, and measurement of skin AGEs might be a surrogate for multiyear mean HbA1c. As certain AGEs fluoresce and skin fluorescence has been demonstrated to correlate with the concentration of skin AGEs, noninvasive measurement by skin intrinsic fluorescence(SIF) facilitates the exploration of the association of mean HbA1c and other clinical/technical factors with SIF using the detailed phenotypic database available in DCCT/EDIC.
Original languageEnglish
Pages (from-to)466-74
JournalDiabetes technology & therapeutics
Volume15
Issue number6
Early online date11 Apr 2013
DOIs
Publication statusPublished - 03 Jun 2013

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