TY - JOUR
T1 - Clinical and technical factors associated with skin intrinsic fluorescence in subjects with type 1 diabetes from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
AU - Cleary, Patricia A
AU - Braffett, Barbara H
AU - Orchard, Trevor
AU - Lyons, Timothy J
AU - Maynard, John
AU - Cowie, Catherine
AU - Gubitosi-Klug, Rose A
AU - Way, Jeff
AU - Anderson, Karen
AU - Barnie, Annette
AU - Villavicencio, Stephan
AU - DCCT/EDIC Research Group
PY - 2013/6/3
Y1 - 2013/6/3
N2 - The Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications(EDIC) studies have established multiyear mean hemoglobin A1c (HbA1c) as predictive of microvascular complications in persons with type 1 diabetes. However, multiyear mean HbA1c is not always available in the clinical setting. Skin advanced glycation end products (AGEs) are thought to partially reflect effects of hyperglycemia over time, and measurement of skin AGEs might be a surrogate for multiyear mean HbA1c. As certain AGEs fluoresce and skin fluorescence has been demonstrated to correlate with the concentration of skin AGEs, noninvasive measurement by skin intrinsic fluorescence(SIF) facilitates the exploration of the association of mean HbA1c and other clinical/technical factors with SIF using the detailed phenotypic database available in DCCT/EDIC.
AB - The Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications(EDIC) studies have established multiyear mean hemoglobin A1c (HbA1c) as predictive of microvascular complications in persons with type 1 diabetes. However, multiyear mean HbA1c is not always available in the clinical setting. Skin advanced glycation end products (AGEs) are thought to partially reflect effects of hyperglycemia over time, and measurement of skin AGEs might be a surrogate for multiyear mean HbA1c. As certain AGEs fluoresce and skin fluorescence has been demonstrated to correlate with the concentration of skin AGEs, noninvasive measurement by skin intrinsic fluorescence(SIF) facilitates the exploration of the association of mean HbA1c and other clinical/technical factors with SIF using the detailed phenotypic database available in DCCT/EDIC.
U2 - 10.1089/dia.2012.0316
DO - 10.1089/dia.2012.0316
M3 - Article
C2 - 23882708
VL - 15
SP - 466
EP - 474
JO - Diabetes technology & therapeutics
JF - Diabetes technology & therapeutics
SN - 1557-8593
IS - 6
ER -
