TY - JOUR
T1 - Clinical and testing protocols for the analysis of epidermal growth factor receptor mutations in East Asian patients with non-small cell lung cancer
T2 - a combined clinical-molecular pathological approach
AU - Salto-Tellez, Manuel
AU - Tsao, Ming-Sound
AU - Shih, Jin-Yuan
AU - Thongprasert, Sumitra
AU - Lu, Shun
AU - Chang, Gee-Chen
AU - Au, Joseph Siu-Kie
AU - Chou, Teh-Ying
AU - Lee, Jong-Seok
AU - Shi, Yuan-Kai
AU - Radzi, Ahmad
AU - Kang, Jin-Hyoung
AU - Kim, Sang-We
AU - Tan, Soo-Yong
AU - Yang, James Chih-Hsin
PY - 2011/10
Y1 - 2011/10
N2 - Several randomized phase III studies in advanced stage non-small cell lung cancer (NSCLC) confirmed the superior response rate and progression-free survival of using epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor as first-line therapy compared with chemotherapy in patients with activating EGFR mutations. Despite the need for EGFR mutation tests to guide first-line therapy in East Asian NSCLC, there are no current standard clinical and testing protocols.
AB - Several randomized phase III studies in advanced stage non-small cell lung cancer (NSCLC) confirmed the superior response rate and progression-free survival of using epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor as first-line therapy compared with chemotherapy in patients with activating EGFR mutations. Despite the need for EGFR mutation tests to guide first-line therapy in East Asian NSCLC, there are no current standard clinical and testing protocols.
KW - Far East
KW - Neoplasm Staging
KW - Receptor, Epidermal Growth Factor
KW - Antineoplastic Agents
KW - Pathology, Molecular
KW - DNA Mutational Analysis
KW - Humans
KW - Drug Resistance, Neoplasm
KW - Asian Continental Ancestry Group
KW - Individualized Medicine
KW - Survival Rate
KW - Lung Neoplasms
KW - Treatment Outcome
KW - Practice Guidelines as Topic
KW - Carcinoma, Non-Small-Cell Lung
KW - Mutation
U2 - 10.1097/JTO.0b013e318227816a
DO - 10.1097/JTO.0b013e318227816a
M3 - Article
C2 - 21869714
VL - 6
SP - 1663
EP - 1669
JO - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
JF - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
SN - 1556-0864
IS - 10
ER -