Clinical and therapeutic relevance of PIM1 kinase in gastric cancer

Benedict Yan, Ee Xuan Yau, Sanjay Samanta, Chee Wee Ong, Kol Jia Yong, Lai Kuan Ng, Bhaskar Bhattacharya, Kiat Hon Lim, Richie Soong, Khay Guan Yeoh, Niantao Deng, Patrick Tan, Yulin Lam, Manuel Salto-Tellez, Singapore Gastric Cancer Consortium

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Gastric cancer is a leading cause of cancer-related mortality, and chemotherapeutic options are currently limited. PIM1 kinase, an oncogene that promotes tumorigenesis in several cancer types, might represent a novel therapeutic target in gastric cancer.
Original languageEnglish
Pages (from-to)188-97
Number of pages10
JournalGBER, Global Built Environment Review (issn: 1474-6824)
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Real-Time Polymerase Chain Reaction
  • Humans
  • In Situ Hybridization, Fluorescence
  • Aged
  • Cell Line, Tumor
  • Gene Expression Regulation, Neoplastic
  • Kaplan-Meier Estimate
  • Protein Array Analysis
  • Proto-Oncogene Proteins c-pim-1
  • Blotting, Western
  • Stomach Neoplasms
  • Middle Aged
  • Immunohistochemistry
  • Cell Transformation, Neoplastic
  • Female
  • Male
  • Survival Analysis

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