Clinical and therapeutic relevance of PIM1 kinase in gastric cancer

Benedict Yan; Ee Xuan Yau; Sanjay Samanta; Chee Wee Ong; Kol Jia Yong; Lai Kuan Ng; Bhaskar Bhattacharya; Kiat Hon Lim; Richie Soong; Khay Guan Yeoh; Niantao Deng; Patrick Tan; Yulin Lam; Manuel Salto-Tellez; Singapore Gastric Cancer Consortium

doi:10.1007/s10120-011-0097-2

Clinical and therapeutic relevance of PIM1 kinase in gastric cancer

Benedict Yan, Ee Xuan Yau, Sanjay Samanta, Chee Wee Ong, Kol Jia Yong, Lai Kuan Ng, Bhaskar Bhattacharya, Kiat Hon Lim, Richie Soong, Khay Guan Yeoh, Niantao Deng, Patrick Tan, Yulin Lam, Manuel Salto-Tellez, Singapore Gastric Cancer Consortium

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Gastric cancer is a leading cause of cancer-related mortality, and chemotherapeutic options are currently limited. PIM1 kinase, an oncogene that promotes tumorigenesis in several cancer types, might represent a novel therapeutic target in gastric cancer.

Original language	English
Pages (from-to)	188-97
Number of pages	10
Journal	GBER, Global Built Environment Review (issn: 1474-6824)
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/s10120-011-0097-2
Publication status	Published - Apr 2012

Keywords

Real-Time Polymerase Chain Reaction
Humans
In Situ Hybridization, Fluorescence
Aged
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Kaplan-Meier Estimate
Protein Array Analysis
Proto-Oncogene Proteins c-pim-1
Blotting, Western
Stomach Neoplasms
Middle Aged
Immunohistochemistry
Cell Transformation, Neoplastic
Female
Male
Survival Analysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10120-011-0097-2

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Yan, B., Yau, E. X., Samanta, S., Ong, C. W., Yong, K. J., Ng, L. K., Bhattacharya, B., Lim, K. H., Soong, R., Yeoh, K. G., Deng, N., Tan, P., Lam, Y., Salto-Tellez, M., & Singapore Gastric Cancer Consortium (2012). Clinical and therapeutic relevance of PIM1 kinase in gastric cancer. GBER, Global Built Environment Review (issn: 1474-6824), 15(2), 188-97. https://doi.org/10.1007/s10120-011-0097-2

Yan, Benedict ; Yau, Ee Xuan ; Samanta, Sanjay ; Ong, Chee Wee ; Yong, Kol Jia ; Ng, Lai Kuan ; Bhattacharya, Bhaskar ; Lim, Kiat Hon ; Soong, Richie ; Yeoh, Khay Guan ; Deng, Niantao ; Tan, Patrick ; Lam, Yulin ; Salto-Tellez, Manuel ; Singapore Gastric Cancer Consortium. / Clinical and therapeutic relevance of PIM1 kinase in gastric cancer. In: GBER, Global Built Environment Review (issn: 1474-6824). 2012 ; Vol. 15, No. 2. pp. 188-97.

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title = "Clinical and therapeutic relevance of PIM1 kinase in gastric cancer",

abstract = "Gastric cancer is a leading cause of cancer-related mortality, and chemotherapeutic options are currently limited. PIM1 kinase, an oncogene that promotes tumorigenesis in several cancer types, might represent a novel therapeutic target in gastric cancer.",

keywords = "Real-Time Polymerase Chain Reaction, Humans, In Situ Hybridization, Fluorescence, Aged, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Kaplan-Meier Estimate, Protein Array Analysis, Proto-Oncogene Proteins c-pim-1, Blotting, Western, Stomach Neoplasms, Middle Aged, Immunohistochemistry, Cell Transformation, Neoplastic, Female, Male, Survival Analysis",

author = "Benedict Yan and Yau, {Ee Xuan} and Sanjay Samanta and Ong, {Chee Wee} and Yong, {Kol Jia} and Ng, {Lai Kuan} and Bhaskar Bhattacharya and Lim, {Kiat Hon} and Richie Soong and Yeoh, {Khay Guan} and Niantao Deng and Patrick Tan and Yulin Lam and Manuel Salto-Tellez and {Singapore Gastric Cancer Consortium}",

year = "2012",

month = apr,

doi = "10.1007/s10120-011-0097-2",

language = "English",

volume = "15",

pages = "188--97",

journal = "GBER, Global Built Environment Review (issn: 1474-6824)",

issn = "1436-3291",

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number = "2",

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Yan, B, Yau, EX, Samanta, S, Ong, CW, Yong, KJ, Ng, LK, Bhattacharya, B, Lim, KH, Soong, R, Yeoh, KG, Deng, N, Tan, P, Lam, Y, Salto-Tellez, M & Singapore Gastric Cancer Consortium 2012, 'Clinical and therapeutic relevance of PIM1 kinase in gastric cancer', GBER, Global Built Environment Review (issn: 1474-6824), vol. 15, no. 2, pp. 188-97. https://doi.org/10.1007/s10120-011-0097-2

Clinical and therapeutic relevance of PIM1 kinase in gastric cancer. / Yan, Benedict; Yau, Ee Xuan; Samanta, Sanjay; Ong, Chee Wee; Yong, Kol Jia; Ng, Lai Kuan; Bhattacharya, Bhaskar; Lim, Kiat Hon; Soong, Richie; Yeoh, Khay Guan; Deng, Niantao; Tan, Patrick; Lam, Yulin; Salto-Tellez, Manuel; Singapore Gastric Cancer Consortium.

In: GBER, Global Built Environment Review (issn: 1474-6824), Vol. 15, No. 2, 04.2012, p. 188-97.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Clinical and therapeutic relevance of PIM1 kinase in gastric cancer

AU - Yan, Benedict

AU - Yau, Ee Xuan

AU - Samanta, Sanjay

AU - Ong, Chee Wee

AU - Yong, Kol Jia

AU - Ng, Lai Kuan

AU - Bhattacharya, Bhaskar

AU - Lim, Kiat Hon

AU - Soong, Richie

AU - Yeoh, Khay Guan

AU - Deng, Niantao

AU - Tan, Patrick

AU - Lam, Yulin

AU - Salto-Tellez, Manuel

AU - Singapore Gastric Cancer Consortium

PY - 2012/4

Y1 - 2012/4

N2 - Gastric cancer is a leading cause of cancer-related mortality, and chemotherapeutic options are currently limited. PIM1 kinase, an oncogene that promotes tumorigenesis in several cancer types, might represent a novel therapeutic target in gastric cancer.

AB - Gastric cancer is a leading cause of cancer-related mortality, and chemotherapeutic options are currently limited. PIM1 kinase, an oncogene that promotes tumorigenesis in several cancer types, might represent a novel therapeutic target in gastric cancer.

KW - Real-Time Polymerase Chain Reaction

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Aged

KW - Cell Line, Tumor

KW - Gene Expression Regulation, Neoplastic

KW - Kaplan-Meier Estimate

KW - Protein Array Analysis

KW - Proto-Oncogene Proteins c-pim-1

KW - Blotting, Western

KW - Stomach Neoplasms

KW - Middle Aged

KW - Immunohistochemistry

KW - Cell Transformation, Neoplastic

KW - Female

KW - Male

KW - Survival Analysis

U2 - 10.1007/s10120-011-0097-2

DO - 10.1007/s10120-011-0097-2

M3 - Article

C2 - 21993851

VL - 15

SP - 188

EP - 197

JO - GBER, Global Built Environment Review (issn: 1474-6824)

JF - GBER, Global Built Environment Review (issn: 1474-6824)

SN - 1436-3291

IS - 2

ER -

Clinical and therapeutic relevance of PIM1 kinase in gastric cancer

Abstract

Keywords

UN SDGs

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