Clinical application of a modular genomics technique in systemic lupus erythematosus: Progress towards precision medicine

Eric Zollars; Sean M. Courtney; Bethany J. Wolf; Norm Allaire; Ann Ranger; Gary Hardiman; Michelle Petri

doi:10.1155/2016/7862962

Clinical application of a modular genomics technique in systemic lupus erythematosus: Progress towards precision medicine

Eric Zollars^*, Sean M. Courtney, Bethany J. Wolf, Norm Allaire, Ann Ranger, Gary Hardiman, Michelle Petri

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

30 Downloads (Pure)

Abstract

Monitoring disease activity in a complex, heterogeneous disease such as lupus is difficult. Both over- and undertreatment lead to damage. Current standard of care serologies are unreliable. Better measures of disease activity are necessary as we move into the era of precision medicine. We show here the use of a data-driven, modular approach to genomic biomarker development within lupus - specifically lupus nephritis.

Original language	English
Article number	7862962
Journal	International Journal of Genomics
Volume	2016
Early online date	01 Aug 2016
DOIs	https://doi.org/10.1155/2016/7862962
Publication status	Early online date - 01 Aug 2016
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics
Pharmaceutical Science

Access to Document

10.1155/2016/7862962Licence: CC BY

Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine
Copyright 2016 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 2 MBLicence: CC BY

Cite this

@article{bae27858885741b3b65816830288ecaa,

title = "Clinical application of a modular genomics technique in systemic lupus erythematosus: Progress towards precision medicine",

abstract = "Monitoring disease activity in a complex, heterogeneous disease such as lupus is difficult. Both over- and undertreatment lead to damage. Current standard of care serologies are unreliable. Better measures of disease activity are necessary as we move into the era of precision medicine. We show here the use of a data-driven, modular approach to genomic biomarker development within lupus - specifically lupus nephritis.",

author = "Eric Zollars and Courtney, {Sean M.} and Wolf, {Bethany J.} and Norm Allaire and Ann Ranger and Gary Hardiman and Michelle Petri",

year = "2016",

month = aug,

day = "1",

doi = "10.1155/2016/7862962",

language = "English",

volume = "2016",

journal = "International Journal of Genomics ",

issn = "2314-436X",

publisher = "John Wiley & Sons Ltd",

}

TY - JOUR

T1 - Clinical application of a modular genomics technique in systemic lupus erythematosus

T2 - Progress towards precision medicine

AU - Zollars, Eric

AU - Courtney, Sean M.

AU - Wolf, Bethany J.

AU - Allaire, Norm

AU - Ranger, Ann

AU - Hardiman, Gary

AU - Petri, Michelle

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Monitoring disease activity in a complex, heterogeneous disease such as lupus is difficult. Both over- and undertreatment lead to damage. Current standard of care serologies are unreliable. Better measures of disease activity are necessary as we move into the era of precision medicine. We show here the use of a data-driven, modular approach to genomic biomarker development within lupus - specifically lupus nephritis.

AB - Monitoring disease activity in a complex, heterogeneous disease such as lupus is difficult. Both over- and undertreatment lead to damage. Current standard of care serologies are unreliable. Better measures of disease activity are necessary as we move into the era of precision medicine. We show here the use of a data-driven, modular approach to genomic biomarker development within lupus - specifically lupus nephritis.

U2 - 10.1155/2016/7862962

DO - 10.1155/2016/7862962

M3 - Article

AN - SCOPUS:84987917082

SN - 2314-436X

VL - 2016

JO - International Journal of Genomics

JF - International Journal of Genomics

M1 - 7862962

ER -

Clinical application of a modular genomics technique in systemic lupus erythematosus: Progress towards precision medicine

Abstract

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this