Clinical consequences of mast cell heterogeneity

P. Forsythe, Madeleine Ennis

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


The heterogeneous morphological, biochemical and functional characteristics of mast cells from different species and from different tissue sites in the same species have been described for over 30 years. Far from being mere histochemical or pharmacological curiosities these differences have far reaching implications for therapeutic practice. This review concentrates on two important areas affected by mast cell heterogeneity, those of adverse reactions to therapeutic agents and the efficacy of anti-allergy therapy.
Original languageEnglish
Pages (from-to)147-154
Number of pages8
JournalInflammation Research
Issue number4
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)
  • Immunology
  • Cell Biology

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