Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients

Alicia J Jenkins, Dongxu Fu, Madona Azar, Julie A Stoner, Derrick G Kaufman, Sarah Zhang, Richard L Klein, Maria F Lopes-Virella, Jian-Xing Ma, Timothy J Lyons, VADT investigators

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Aim: To determine if serum pigment epithelium-derived factor (PEDF) levels in Type 2 diabetes are related to vascular risk factors and renal function. Methods: PEDF was quantified by ELISA in a cross-sectional study of 857 male Veterans Affairs Diabetes Trial (VADT) subjects, and associations with cardiovascular risk factors and renal function were determined. In a subset (n = 246) in whom serum was obtained early in the VADT (2.0 ± 0.3 years post-randomization), PEDF was related to longitudinal changes in renal function over 3.1 years. Results: Cross-sectional study: In multivariate regression models, PEDF was positively associated with serum triglycerides, waist-to-hip ratio, serum creatinine, use of ACE inhibitors or angiotensin receptor blockers, and use of lipid-lowering agents; it was negatively associated with HDL-C (all p < 0.05). Longitudinal study: PEDF was not associated with changes in renal function over 3.1 years (p > 0.09). Conclusions: Serum PEDF in Type 2 diabetic men was cross-sectionally associated with dyslipidemia, body habitus, use of common drugs for blood pressure and dyslipidemia, and indices of renal function; however, PEDF was not associated with renal decline over 3.1 years.
Original languageEnglish
JournalJournal of diabetes and its complications
Issue number3
Early online date17 Jan 2014
Publication statusPublished - May 2014

Bibliographical note

Copyright © 2014 Elsevier Inc. All rights reserved.

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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