Clinical Determinants of Response to Irinotecan-Based Therapy Derived from Cell Line Models

Wendy Allen, Victoria Coyle, Puthen Jithesh, Irina Proutski, Leanne Stevenson, Catherine Fenning, Daniel Longley, Richard Wilson, M. Gordon, H.J. Lenz, Patrick Johnston

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Purpose: In an attempt to identify genes that are involved in resistance to SN38, the active metabolite of irinotecan (also known as CPT-11), we carried out DNA microarray profiling of matched HCT116 human colon cancer parental cell lines and SN38-resistant cell lines following treatment with SN38 over time.
Original languageEnglish
Pages (from-to)6647-6655
Number of pages9
JournalClinical Cancer Research
Volume14
Issue number20
DOIs
Publication statusPublished - 15 Oct 2008

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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