Clinical Determinants of Response to Irinotecan-Based Therapy Derived from Cell Line Models

Wendy Allen; Victoria Coyle; Puthen Jithesh; Irina Proutski; Leanne Stevenson; Catherine Fenning; Daniel Longley; Richard Wilson; M. Gordon; H.J. Lenz; Patrick Johnston

doi:10.1158/1078-0432.CCR-08-0452

Clinical Determinants of Response to Irinotecan-Based Therapy Derived from Cell Line Models

Wendy Allen, Victoria Coyle, Puthen Jithesh, Irina Proutski, Leanne Stevenson, Catherine Fenning, Daniel Longley, Richard Wilson, M. Gordon, H.J. Lenz, Patrick Johnston

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Purpose: In an attempt to identify genes that are involved in resistance to SN38, the active metabolite of irinotecan (also known as CPT-11), we carried out DNA microarray profiling of matched HCT116 human colon cancer parental cell lines and SN38-resistant cell lines following treatment with SN38 over time.

Original language	English
Pages (from-to)	6647-6655
Number of pages	9
Journal	Clinical Cancer Research
Volume	14
Issue number	20
DOIs	https://doi.org/10.1158/1078-0432.CCR-08-0452
Publication status	Published - 15 Oct 2008

ASJC Scopus subject areas

Cancer Research
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/1078-0432.CCR-08-0452

Cite this

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abstract = "Purpose: In an attempt to identify genes that are involved in resistance to SN38, the active metabolite of irinotecan (also known as CPT-11), we carried out DNA microarray profiling of matched HCT116 human colon cancer parental cell lines and SN38-resistant cell lines following treatment with SN38 over time.",

author = "Wendy Allen and Victoria Coyle and Puthen Jithesh and Irina Proutski and Leanne Stevenson and Catherine Fenning and Daniel Longley and Richard Wilson and M. Gordon and H.J. Lenz and Patrick Johnston",

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AU - Allen, Wendy

AU - Coyle, Victoria

AU - Jithesh, Puthen

AU - Proutski, Irina

AU - Stevenson, Leanne

AU - Fenning, Catherine

AU - Longley, Daniel

AU - Wilson, Richard

AU - Gordon, M.

AU - Lenz, H.J.

AU - Johnston, Patrick

PY - 2008/10/15

Y1 - 2008/10/15

N2 - Purpose: In an attempt to identify genes that are involved in resistance to SN38, the active metabolite of irinotecan (also known as CPT-11), we carried out DNA microarray profiling of matched HCT116 human colon cancer parental cell lines and SN38-resistant cell lines following treatment with SN38 over time.

AB - Purpose: In an attempt to identify genes that are involved in resistance to SN38, the active metabolite of irinotecan (also known as CPT-11), we carried out DNA microarray profiling of matched HCT116 human colon cancer parental cell lines and SN38-resistant cell lines following treatment with SN38 over time.

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U2 - 10.1158/1078-0432.CCR-08-0452

DO - 10.1158/1078-0432.CCR-08-0452

M3 - Article

SN - 1078-0432

VL - 14

SP - 6647

EP - 6655

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 20

ER -

Clinical Determinants of Response to Irinotecan-Based Therapy Derived from Cell Line Models

Abstract

ASJC Scopus subject areas

UN SDGs

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